3kw1
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3kw1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KW1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3kw1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KW1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ENW:2-({N-[(2S)-2,4-DIHYDROXY-3,3-DIMETHYLBUTANOYL]-BETA-ALANYL}AMINO)ETHYL+FLUOROACETATE'>ENW</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ENW:2-({N-[(2S)-2,4-DIHYDROXY-3,3-DIMETHYLBUTANOYL]-BETA-ALANYL}AMINO)ETHYL+FLUOROACETATE'>ENW</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kuv|3kuv]], [[3kuw|3kuw]], [[3kv7|3kv7]], [[3kv8|3kv8]], [[3kvi|3kvi]], [[3kvu|3kvu]], [[3kvz|3kvz]], [[3kx7|3kx7]], [[3kx8|3kx8]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kuv|3kuv]], [[3kuw|3kuw]], [[3kv7|3kv7]], [[3kv8|3kv8]], [[3kvi|3kvi]], [[3kvu|3kvu]], [[3kvz|3kvz]], [[3kx7|3kx7]], [[3kx8|3kx8]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FlK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29303 Streptomyces cattleya])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FlK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29303 Streptomyces cattleya])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kw1 RCSB], [http://www.ebi.ac.uk/pdbsum/3kw1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kw1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kw1 RCSB], [http://www.ebi.ac.uk/pdbsum/3kw1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q1EMV2_STRCT Q1EMV2_STRCT]] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.,Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL J Biol Chem. 2010 Jul 16;285(29):22495-504. Epub 2010 Apr 29. PMID:20430898<ref>PMID:20430898</ref> | Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.,Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL J Biol Chem. 2010 Jul 16;285(29):22495-504. Epub 2010 Apr 29. PMID:20430898<ref>PMID:20430898</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Thioesterase|Thioesterase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Streptomyces cattleya]] | [[Category: Streptomyces cattleya]] | ||
| - | [[Category: Blundell, T L | + | [[Category: Blundell, T L]] |
| - | [[Category: Chirgadze, D Y | + | [[Category: Chirgadze, D Y]] |
| - | [[Category: Dias, M V.B | + | [[Category: Dias, M V.B]] |
| - | [[Category: Huang, F | + | [[Category: Huang, F]] |
| - | [[Category: Leadlay, P F | + | [[Category: Leadlay, P F]] |
| - | [[Category: Spencer, J B | + | [[Category: Spencer, J B]] |
[[Category: Spiteller, D]] | [[Category: Spiteller, D]] | ||
| - | [[Category: Tosin, M | + | [[Category: Tosin, M]] |
| - | [[Category: Valentine, E F | + | [[Category: Valentine, E F]] |
[[Category: Fluoroacetyl-coa thioesterase flk]] | [[Category: Fluoroacetyl-coa thioesterase flk]] | ||
[[Category: Hot-dog folding]] | [[Category: Hot-dog folding]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Thioesterase]] | [[Category: Thioesterase]] | ||
Revision as of 20:25, 24 December 2014
Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA FlK - Wild type FlK in complex with FAcOPan
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