This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3nv0
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3nv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3nv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C15H11.6, nxf-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans]), nxt-1, nxt1, Y71F9AM.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C15H11.6, nxf-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans]), nxt-1, nxt1, Y71F9AM.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv0 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv0 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NXF2_CAEEL NXF2_CAEEL]] May be involved in the export of cellular mRNA to the cytoplasm (By similarity). [[http://www.uniprot.org/uniprot/NXT1_CAEEL NXT1_CAEEL]] Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 13: | Line 15: | ||
The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.,Kerkow DE, Carmel AB, Menichelli E, Ambrus G, Hills RD Jr, Gerace L, Williamson JR J Mol Biol. 2012 Jan 27;415(4):649-65. doi: 10.1016/j.jmb.2011.11.027. Epub 2011 , Nov 22. PMID:22123199<ref>PMID:22123199</ref> | The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.,Kerkow DE, Carmel AB, Menichelli E, Ambrus G, Hills RD Jr, Gerace L, Williamson JR J Mol Biol. 2012 Jan 27;415(4):649-65. doi: 10.1016/j.jmb.2011.11.027. Epub 2011 , Nov 22. PMID:22123199<ref>PMID:22123199</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
| - | [[Category: Carmel, A B | + | [[Category: Carmel, A B]] |
| - | [[Category: Kerkow, D E | + | [[Category: Kerkow, D E]] |
| - | [[Category: Williamson, J R | + | [[Category: Williamson, J R]] |
[[Category: Beta sheet heterodimer interface]] | [[Category: Beta sheet heterodimer interface]] | ||
[[Category: Cation-pi interaction]] | [[Category: Cation-pi interaction]] | ||
Revision as of 12:50, 25 December 2014
Crystal structure and mutational analysis of the NXF2/NXT1 heterodimeric complex from caenorhabditis elegans at 1.84 A resolution
| |||||||||||
Categories: Caenorhabditis elegans | Carmel, A B | Kerkow, D E | Williamson, J R | Beta sheet heterodimer interface | Cation-pi interaction | Intramonomer buried water | Mrna transport | Novel surface exposed pocket | Ntf2-like domain | Ntf2-plug | Nucleoporin binding pocket | Nucleus | Nxf-loop | Pi-pi interaction | Rna binding-protein transport complex | Rna-binding | Water mediated interface
