3ei0
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ei0]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EI0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ei0]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EI0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ehz|3ehz]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ehz|3ehz]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ei0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ei0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ei0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ei0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ei0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ei0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ei0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ei0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q7NDN8_GLOVI Q7NDN8_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.,Hilf RJ, Dutzler R Nature. 2009 Jan 1;457(7225):115-8. Epub 2008 Nov 5. PMID:18987630<ref>PMID:18987630</ref> | Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.,Hilf RJ, Dutzler R Nature. 2009 Jan 1;457(7225):115-8. Epub 2008 Nov 5. PMID:18987630<ref>PMID:18987630</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Gloeobacter violaceus]] | [[Category: Gloeobacter violaceus]] | ||
| - | [[Category: Dutzler, R | + | [[Category: Dutzler, R]] |
| - | [[Category: Hilf, R J.C | + | [[Category: Hilf, R J.C]] |
[[Category: Cation selective channel]] | [[Category: Cation selective channel]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Pentameric ligand gated ion channel]] | [[Category: Pentameric ligand gated ion channel]] | ||
[[Category: Prokaryotic cys-loop receptor]] | [[Category: Prokaryotic cys-loop receptor]] | ||
Revision as of 18:24, 24 December 2014
Structure of the E221A mutant of the Gloebacter violaceus pentameric ligand gated ion channnel (GLIC)
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