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User:John S. de Banzie/GlobularProtein

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(New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for you...)
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==Your Heading Here (maybe something like 'Structure')==
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==Simple Example of Globular Protein Structure==
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='1qgv' size='400' side='right' caption='Human U5 Spliceosomal protein U5-15kD, [[1qgv]]' scene='58/587846/1qgv_sf/2'>
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This is a default text for your page '''John S. de Banzie/GlobularProtein'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==
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Most proteins are globular proteins. This page uses the human spliceosomal protein U5-15kD to illustrate some basic features of globular proteins. Specifically:
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== Disease ==
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1. Globular proteins are compact and rarely have internal cavities.
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== Relevance ==
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2. Globular protein structure is primarily stabilized by the hydrophobic interaction.
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== Structural highlights ==
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3. Globular proteins have mixed secondary structure.
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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(U5-15kD is a component of the U5 small nuclear ribosomal protein particle (snRNP). This in turn is a component of the spliceosome, a macromolecular assembly involved in converting primary transcripts into functional mRNAs. U5-15kD was chosen for this page because it is small, but has all of the features necessary to illustrate the points being made.)
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</StructureSection>
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The <scene name='58/587846/1qgv_sf/2'>space filling model</scene> of the protein shows that the protein is compact, globular, and has no signs of internal cavities.
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== References ==
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<references/>
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Colouring the <scene name='58/587846/1qgv_sf_pnp/2'>hydrophilic and hydrophobic residues</scene> shows that the interior of the protein is primarily hydrophobic (red) and the exterior is primarily hydrophilic (blue).
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The <scene name='58/587846/1qgv_ca/2'>cartoon view</scene> of the protein shows that the protein has mixed secondary structure. There are three segments of alpha-helix (magenta), six segments of beta-pleated sheet (gold), both parallel and anti-parallel, and some irregular regions (white).

Revision as of 20:33, 31 May 2014

Simple Example of Globular Protein Structure

Human U5 Spliceosomal protein U5-15kD, 1qgv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

John S. de Banzie

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