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4o5t
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4o5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O5T FirstGlance]. <br> | <table><tr><td colspan='2'>[[4o5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O5T FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XDA:4-{[2-(PHOSPHONOOXY)ETHYL]CARBAMOYL}BENZYL+[(1R,6S)-6-(DIMETHYLCARBAMOYL)CYCLOHEX-2-EN-1-YL]CARBAMATE'>XDA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XDA:4-{[2-(PHOSPHONOOXY)ETHYL]CARBAMOYL}BENZYL+[(1R,6S)-6-(DIMETHYLCARBAMOYL)CYCLOHEX-2-EN-1-YL]CARBAMATE'>XDA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u0s|3u0s]], [[3i1c|3i1c]], [[1e1a|1e1a]], [[4o5s|4o5s]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u0s|3u0s]], [[3i1c|3i1c]], [[1e1a|1e1a]], [[4o5s|4o5s]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diisopropyl-fluorophosphatase Diisopropyl-fluorophosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.2 3.1.8.2] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o5t RCSB], [http://www.ebi.ac.uk/pdbsum/4o5t PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o5t RCSB], [http://www.ebi.ac.uk/pdbsum/4o5t PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DFPA_LOLVU DFPA_LOLVU]] Biological function and substrate unknown. However, it is capable of acting on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including nerve gases).<ref>PMID:15966726</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase.,Preiswerk N, Beck T, Schulz JD, Milovnik P, Mayer C, Siegel JB, Baker D, Hilvert D Proc Natl Acad Sci U S A. 2014 May 20. pii: 201401073. PMID:24847076<ref>PMID:24847076</ref> | Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase.,Preiswerk N, Beck T, Schulz JD, Milovnik P, Mayer C, Siegel JB, Baker D, Hilvert D Proc Natl Acad Sci U S A. 2014 May 20. pii: 201401073. PMID:24847076<ref>PMID:24847076</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Diisopropyl-fluorophosphatase]] | [[Category: Diisopropyl-fluorophosphatase]] | ||
| - | [[Category: Beck, T | + | [[Category: Beck, T]] |
| - | [[Category: Hilvert, D | + | [[Category: Hilvert, D]] |
| - | [[Category: Mayer, C | + | [[Category: Mayer, C]] |
| - | [[Category: Preiswerk, N | + | [[Category: Preiswerk, N]] |
[[Category: Artificial catalyst]] | [[Category: Artificial catalyst]] | ||
[[Category: Beta-propeller]] | [[Category: Beta-propeller]] | ||
Revision as of 15:19, 24 December 2014
Crystal structure of Diels-Alderase CE20 in complex with a product analog
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Categories: Diisopropyl-fluorophosphatase | Beck, T | Hilvert, D | Mayer, C | Preiswerk, N | Artificial catalyst | Beta-propeller | Catalyst for cycloaddition | Computer-aided design | De novo protein | Diels-alder reaction | Diels-alderase | Directed evolution | Enzyme design | Enzyme-product analog complexes' | Helix-loop-helix | Hydrolase | Protein engineering | Substrate specificity
