1aq1
From Proteopedia
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|SITE= <scene name='pdbsite=STB:Staurosporine+Binding+Site'>STB</scene> | |SITE= <scene name='pdbsite=STB:Staurosporine+Binding+Site'>STB</scene> | ||
|LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene> | |LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene> | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/ | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aq1 OCA], [http://www.ebi.ac.uk/pdbsum/1aq1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aq1 RCSB]</span> | ||
}} | }} | ||
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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334743 9334743] | Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334743 9334743] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Transferred entry: 2 7.11 1]] | ||
[[Category: Brown, N R.]] | [[Category: Brown, N R.]] | ||
[[Category: Endicott, J A.]] | [[Category: Endicott, J A.]] | ||
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[[Category: Noble, M E.M.]] | [[Category: Noble, M E.M.]] | ||
[[Category: Tunnah, P.]] | [[Category: Tunnah, P.]] | ||
| - | [[Category: STU]] | ||
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
[[Category: cell division]] | [[Category: cell division]] | ||
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[[Category: staurosporine]] | [[Category: staurosporine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:45:15 2008'' |
Revision as of 15:45, 30 March 2008
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| , resolution 2.0Å | |||||||
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| Sites: | |||||||
| Ligands: | |||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Overview
Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.
About this Structure
1AQ1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743
Page seeded by OCA on Sun Mar 30 18:45:15 2008
