3p1x
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3p1x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P1X FirstGlance]. <br> | <table><tr><td colspan='2'>[[3p1x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P1X FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p1x RCSB], [http://www.ebi.ac.uk/pdbsum/3p1x PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p1x RCSB], [http://www.ebi.ac.uk/pdbsum/3p1x PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ILF3_HUMAN ILF3_HUMAN]] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).<ref>PMID:7519613</ref> <ref>PMID:9442054</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton, T B | + | [[Category: Acton, T B]] |
| - | [[Category: Baran, M C | + | [[Category: Baran, M C]] |
| - | [[Category: Cunningham, K | + | [[Category: Cunningham, K]] |
| - | [[Category: Hunt, J F | + | [[Category: Hunt, J F]] |
| - | [[Category: Janjua, H | + | [[Category: Janjua, H]] |
| - | [[Category: Liu, J | + | [[Category: Liu, J]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Neely, H | + | [[Category: Neely, H]] |
| - | [[Category: Owens, L | + | [[Category: Owens, L]] |
| - | [[Category: Seetharaman, J | + | [[Category: Seetharaman, J]] |
| - | [[Category: Tong, L | + | [[Category: Tong, L]] |
| - | [[Category: Wang, D | + | [[Category: Wang, D]] |
| - | [[Category: Xiao, R | + | [[Category: Xiao, R]] |
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Transcription regulator]] | [[Category: Transcription regulator]] | ||
Revision as of 02:33, 25 December 2014
Crystal structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E
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