3ruk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ruk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RUK FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ruk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RUK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AER:ABIRATERONE'>AER</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AER:ABIRATERONE'>AER</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3swz|3swz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3swz|3swz]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP17, CYP17A1, S17AH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP17, CYP17A1, S17AH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Steroid_17-alpha-monooxygenase Steroid 17-alpha-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.9 1.14.99.9] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Steroid_17-alpha-monooxygenase Steroid 17-alpha-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.9 1.14.99.9] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ruk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ruk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ruk RCSB], [http://www.ebi.ac.uk/pdbsum/3ruk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ruk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ruk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ruk RCSB], [http://www.ebi.ac.uk/pdbsum/3ruk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
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Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.,Devore NM, Scott EE Nature. 2012 Jan 22. doi: 10.1038/nature10743. PMID:22266943<ref>PMID:22266943</ref> | Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.,Devore NM, Scott EE Nature. 2012 Jan 22. doi: 10.1038/nature10743. PMID:22266943<ref>PMID:22266943</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Steroid 17-alpha-monooxygenase]] | [[Category: Steroid 17-alpha-monooxygenase]] | ||
| - | [[Category: DeVore, N M | + | [[Category: DeVore, N M]] |
| - | [[Category: Scott, E E | + | [[Category: Scott, E E]] |
| - | + | ||
[[Category: 17a-hydroxylase]] | [[Category: 17a-hydroxylase]] | ||
[[Category: 17a-hydroxylation]] | [[Category: 17a-hydroxylation]] | ||
Revision as of 09:07, 4 January 2015
Human Cytochrome P450 CYP17A1 in complex with Abiraterone
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Categories: Homo sapiens | Steroid 17-alpha-monooxygenase | DeVore, N M | Scott, E E | 17a-hydroxylase | 17a-hydroxylation | 20-lyase | Abiraterone | Cyp17a1 | Cytochrome p450 | Cytochrome p450 oxidoreductase | Endoplasmic reticulum | Galeterone | Heme protein | Membrane | Microsome | Monooxygenase | Oxidoreductase-oxidoreductase inhibitor complex | P450 17a1 | Zytiga
