3r2j

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3r2j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R2J FirstGlance]. <br>
<table><tr><td colspan='2'>[[3r2j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R2J FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NIO:NICOTINIC+ACID'>NIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NIO:NICOTINIC+ACID'>NIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LinJ01.0460 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5671 Leishmania infantum])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LinJ01.0460 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5671 Leishmania infantum])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamidase Nicotinamidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.19 3.5.1.19] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamidase Nicotinamidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.19 3.5.1.19] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r2j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r2j RCSB], [http://www.ebi.ac.uk/pdbsum/3r2j PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r2j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r2j RCSB], [http://www.ebi.ac.uk/pdbsum/3r2j PDBsum]</span></td></tr>
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<table>
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</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation.,Gazanion E, Garcia D, Silvestre R, Gerard C, Guichou J, Labesse G, Seveno M, Cordeiro-Da-Silva A, Ouaissi A, Sereno D, Vergnes B Mol Microbiol. 2011 Aug 8. doi: 10.1111/j.1365-2958.2011.07799.x. PMID:21819459<ref>PMID:21819459</ref>
The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation.,Gazanion E, Garcia D, Silvestre R, Gerard C, Guichou J, Labesse G, Seveno M, Cordeiro-Da-Silva A, Ouaissi A, Sereno D, Vergnes B Mol Microbiol. 2011 Aug 8. doi: 10.1111/j.1365-2958.2011.07799.x. PMID:21819459<ref>PMID:21819459</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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[[Category: Leishmania infantum]]
[[Category: Leishmania infantum]]
[[Category: Nicotinamidase]]
[[Category: Nicotinamidase]]
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[[Category: Garcia, D.]]
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[[Category: Garcia, D]]
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[[Category: Gazanion, E.]]
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[[Category: Gazanion, E]]
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[[Category: Guichou, J F.]]
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[[Category: Guichou, J F]]
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[[Category: Labesse, G.]]
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[[Category: Labesse, G]]
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[[Category: Sereno, D.]]
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[[Category: Sereno, D]]
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[[Category: Vergnes, B.]]
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[[Category: Vergnes, B]]
[[Category: Alpha/beta-hydrolase-like]]
[[Category: Alpha/beta-hydrolase-like]]
[[Category: Cytoplasmic]]
[[Category: Cytoplasmic]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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[[Category: Nicotinamidase]]
 

Revision as of 22:37, 3 January 2015

Crystal Structure of PnC1 from L. infantum in complex with nicotinate

3r2j, resolution 2.68Å

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