1aux

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 1aux |SIZE=350|CAPTION= <scene name='initialview01'>1aux</scene>, resolution 2.30&Aring;
|PDB= 1aux |SIZE=350|CAPTION= <scene name='initialview01'>1aux</scene>, resolution 2.30&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=SAP:ADENOSINE-5'-DIPHOSPHATE MONOTHIOPHOSPHATE'>SAP</scene>
+
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=SAP:ADENOSINE-5&#39;-DIPHOSPHATE MONOTHIOPHOSPHATE'>SAP</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
Line 33: Line 33:
[[Category: synapsin ia c-domain]]
[[Category: synapsin ia c-domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:02:34 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:10:20 2008''

Revision as of 09:10, 23 March 2008

Image:1aux.gif


PDB ID 1aux

Drag the structure with the mouse to rotate
, resolution 2.30Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE C DOMAIN OF SYNAPSIN IA FROM BOVINE BRAIN WITH CALCIUM ATP-GAMMA-S BOUND


Overview

Synapsins are abundant synaptic vesicle proteins with an essential regulatory function in the nerve terminal. We determined the crystal structure of a fragment (synC) consisting of residues 110-420 of bovine synapsin I; synC coincides with the large middle domain (C-domain), the most conserved domain of synapsins. SynC molecules are folded into compact domains and form closely associated dimers. SynC monomers are strikingly similar in structure to a family of ATP-utilizing enzymes, which includes glutathione synthetase and D-alanine:D-alanine ligase. SynC binds ATP in a Ca2+-dependent manner. The crystal structure of synC in complex with ATPgammaS and Ca2+ explains the preference of synC for Ca2+ over Mg2+. Our results suggest that synapsins may also be ATP-utilizing enzymes.

About this Structure

1AUX is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Synapsin I is structurally similar to ATP-utilizing enzymes., Esser L, Wang CR, Hosaka M, Smagula CS, Sudhof TC, Deisenhofer J, EMBO J. 1998 Feb 16;17(4):977-84. PMID:9463376

Page seeded by OCA on Sun Mar 23 11:10:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aux"
Personal tools