3rty
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3rty]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RTY FirstGlance]. <br> | <table><tr><td colspan='2'>[[3rty]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RTY FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">per, CG2647 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">per, CG2647 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rty RCSB], [http://www.ebi.ac.uk/pdbsum/3rty PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rty RCSB], [http://www.ebi.ac.uk/pdbsum/3rty PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PER_DROME PER_DROME]] Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structure of an enclosed dimer formed by the Drosophila period protein.,King HA, Hoelz A, Crane BR, Young MW J Mol Biol. 2011 Oct 28;413(3):561-72. Epub 2011 Sep 3. PMID:21907720<ref>PMID:21907720</ref> | Structure of an enclosed dimer formed by the Drosophila period protein.,King HA, Hoelz A, Crane BR, Young MW J Mol Biol. 2011 Oct 28;413(3):561-72. Epub 2011 Sep 3. PMID:21907720<ref>PMID:21907720</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Crane, B R | + | [[Category: Crane, B R]] |
| - | [[Category: Hoelz, A | + | [[Category: Hoelz, A]] |
| - | [[Category: King, H A | + | [[Category: King, H A]] |
| - | [[Category: Young, M W | + | [[Category: Young, M W]] |
[[Category: Circadian clock protein]] | [[Category: Circadian clock protein]] | ||
[[Category: Pas domain]] | [[Category: Pas domain]] | ||
[[Category: Signalling]] | [[Category: Signalling]] | ||
[[Category: Timeless]] | [[Category: Timeless]] | ||
Revision as of 19:43, 25 December 2014
Structure of an Enclosed Dimer Formed by The Drosophila Period Protein
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