3sam
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3sam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SAM FirstGlance]. <br> | <table><tr><td colspan='2'>[[3sam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SAM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3saq|3saq]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3saq|3saq]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D13, D13L, VACWR118 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D13, D13L, VACWR118 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sam RCSB], [http://www.ebi.ac.uk/pdbsum/3sam PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sam RCSB], [http://www.ebi.ac.uk/pdbsum/3sam PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/REFR_VACCW REFR_VACCW]] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Membrane remodeling by the double-barrel scaffolding protein of poxvirus.,Hyun JK, Accurso C, Hijnen M, Schult P, Pettikiriarachchi A, Mitra AK, Coulibaly F PLoS Pathog. 2011 Sep;7(9):e1002239. Epub 2011 Sep 8. PMID:21931553<ref>PMID:21931553</ref> | Membrane remodeling by the double-barrel scaffolding protein of poxvirus.,Hyun JK, Accurso C, Hijnen M, Schult P, Pettikiriarachchi A, Mitra AK, Coulibaly F PLoS Pathog. 2011 Sep;7(9):e1002239. Epub 2011 Sep 8. PMID:21931553<ref>PMID:21931553</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
| - | [[Category: Coulibaly, F | + | [[Category: Coulibaly, F]] |
[[Category: Double-barrel]] | [[Category: Double-barrel]] | ||
[[Category: Jelly-roll]] | [[Category: Jelly-roll]] | ||
Revision as of 16:19, 25 December 2014
Structure of D13, the scaffolding protein of vaccinia virus (mutant D513G)
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