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2c7t
From Proteopedia
(New page: 200px<br /> <applet load="2c7t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c7t, resolution 2.10Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C7T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]] with SO4 and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C7T OCA]]. | + | 2C7T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]] with SO4 and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C7T OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:44:00 2007'' |
Revision as of 06:39, 30 October 2007
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CRYSTAL STRUCTURE OF THE PLP-BOUND FORM OF BTRR, A DUAL FUNCTIONAL AMINOTRANSFERASE INVOLVED IN BUTIROSIN BIOSYNTHESIS.
Overview
The aminotransferase (BtrR), which is involved in the biosynthesis of, butirosin, a 2-deoxystreptamine (2-DOS)-containing aminoglycoside, antibiotic produced by Bacillus circulans, catalyses the pyridoxal, phosphate (PLP)-dependent transamination reaction both of, 2-deoxy-scyllo-inosose to 2-deoxy-scyllo-inosamine and of, amino-dideoxy-scyllo-inosose to 2-DOS. The high-resolution crystal, structures of the PLP- and PMP-bound forms of BtrR aminotransferase from, B. circulans were solved at resolutions of 2.1 A and 1.7 A with, R(factor)/R(free) values of 17.4/20.6 and 19.9/21.9, respectively. BtrR, has a fold characteristic of the aspartate aminotransferase family, and, sequence and structure analysis categorises it as a member of SMAT, (secondary metabolite aminotransferases) subfamily. It ... [(full description)]
About this Structure
2C7T is a [Single protein] structure of sequence from [Bacillus circulans] with SO4 and PLP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis., Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB, Proteins. 2006 Oct 1;65(1):220-30. PMID:16894611
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