3zv7
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zgb|1zgb]], [[1qti|1qti]], [[1amn|1amn]], [[1e66|1e66]], [[2vq6|2vq6]], [[2ack|2ack]], [[2j3d|2j3d]], [[1qii|1qii]], [[2ckm|2ckm]], [[1dx6|1dx6]], [[1qie|1qie]], [[1qij|1qij]], [[1acl|1acl]], [[1odc|1odc]], [[1w4l|1w4l]], [[2cmf|2cmf]], [[2wg0|2wg0]], [[2j3q|2j3q]], [[1gqs|1gqs]], [[2j4f|2j4f]], [[1e3q|1e3q]], [[1qik|1qik]], [[2dfp|2dfp]], [[2c5f|2c5f]], [[1ea5|1ea5]], [[1qif|1qif]], [[2vjc|2vjc]], [[1eea|1eea]], [[2vjb|2vjb]], [[1qig|1qig]], [[1qid|1qid]], [[1zgc|1zgc]], [[2wfz|2wfz]], [[2vjd|2vjd]], [[1jjb|1jjb]], [[2wg1|2wg1]], [[1ut6|1ut6]], [[2vt6|2vt6]], [[2wg2|2wg2]], [[2w9i|2w9i]], [[2vt7|2vt7]], [[2cek|2cek]], [[1qim|1qim]], [[1jga|1jga]], [[1gpk|1gpk]], [[3ace|3ace]], [[1oce|1oce]], [[1w6r|1w6r]], [[1som|1som]], [[1vxo|1vxo]], [[2vja|2vja]], [[2w6c|2w6c]], [[1cfj|1cfj]], [[2v96|2v96]], [[1ax9|1ax9]], [[1w76|1w76]], [[1u65|1u65]], [[1h22|1h22]], [[1eve|1eve]], [[2c4h|2c4h]], [[1gqr|1gqr]], [[2va9|2va9]], [[2ace|2ace]], [[1vxr|1vxr]], [[4ace|4ace]], [[2c58|2c58]], [[1hbj|1hbj]], [[1w75|1w75]], [[1vot|1vot]], [[2c5g|2c5g]], [[2v98|2v98]], [[1jgb|1jgb]], [[2xi4|2xi4]], [[1gpn|1gpn]], [[1qih|1qih]], [[1h23|1h23]], [[1fss|1fss]], [[1acj|1acj]], [[2v97|2v97]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zgb|1zgb]], [[1qti|1qti]], [[1amn|1amn]], [[1e66|1e66]], [[2vq6|2vq6]], [[2ack|2ack]], [[2j3d|2j3d]], [[1qii|1qii]], [[2ckm|2ckm]], [[1dx6|1dx6]], [[1qie|1qie]], [[1qij|1qij]], [[1acl|1acl]], [[1odc|1odc]], [[1w4l|1w4l]], [[2cmf|2cmf]], [[2wg0|2wg0]], [[2j3q|2j3q]], [[1gqs|1gqs]], [[2j4f|2j4f]], [[1e3q|1e3q]], [[1qik|1qik]], [[2dfp|2dfp]], [[2c5f|2c5f]], [[1ea5|1ea5]], [[1qif|1qif]], [[2vjc|2vjc]], [[1eea|1eea]], [[2vjb|2vjb]], [[1qig|1qig]], [[1qid|1qid]], [[1zgc|1zgc]], [[2wfz|2wfz]], [[2vjd|2vjd]], [[1jjb|1jjb]], [[2wg1|2wg1]], [[1ut6|1ut6]], [[2vt6|2vt6]], [[2wg2|2wg2]], [[2w9i|2w9i]], [[2vt7|2vt7]], [[2cek|2cek]], [[1qim|1qim]], [[1jga|1jga]], [[1gpk|1gpk]], [[3ace|3ace]], [[1oce|1oce]], [[1w6r|1w6r]], [[1som|1som]], [[1vxo|1vxo]], [[2vja|2vja]], [[2w6c|2w6c]], [[1cfj|1cfj]], [[2v96|2v96]], [[1ax9|1ax9]], [[1w76|1w76]], [[1u65|1u65]], [[1h22|1h22]], [[1eve|1eve]], [[2c4h|2c4h]], [[1gqr|1gqr]], [[2va9|2va9]], [[2ace|2ace]], [[1vxr|1vxr]], [[4ace|4ace]], [[2c58|2c58]], [[1hbj|1hbj]], [[1w75|1w75]], [[1vot|1vot]], [[2c5g|2c5g]], [[2v98|2v98]], [[1jgb|1jgb]], [[2xi4|2xi4]], [[1gpn|1gpn]], [[1qih|1qih]], [[1h23|1h23]], [[1fss|1fss]], [[1acj|1acj]], [[2v97|2v97]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3zv7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.,Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D Biochem J. 2012 Jun 1;444(2):269-77. PMID:22390827<ref>PMID:22390827</ref> | Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.,Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D Biochem J. 2012 Jun 1;444(2):269-77. PMID:22390827<ref>PMID:22390827</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
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[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Torpedo californica]] | [[Category: Torpedo californica]] | ||
| - | [[Category: Bartolucci, C | + | [[Category: Bartolucci, C]] |
| - | [[Category: Greig, N H | + | [[Category: Greig, N H]] |
| - | [[Category: Lamba, D | + | [[Category: Lamba, D]] |
| - | [[Category: Stojan, J | + | [[Category: Stojan, J]] |
[[Category: Anti-alzheimer drug]] | [[Category: Anti-alzheimer drug]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Neurotransmitter cleavage]] | [[Category: Neurotransmitter cleavage]] | ||
Revision as of 19:59, 25 December 2014
Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine
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