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3zt1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zt1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZT1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3zt1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZT1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OM1:(4-CARBOXY-1,3-BENZODIOXOL-5-YL)METHYL-[[2-[(4-METHOXYPHENYL)METHYLCARBAMOYL]PHENYL]METHYL]AZANIUM'>OM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OM1:(4-CARBOXY-1,3-BENZODIOXOL-5-YL)METHYL-[[2-[(4-METHOXYPHENYL)METHYLCARBAMOYL]PHENYL]METHYL]AZANIUM'>OM1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zsq|3zsq]], [[3zt2|3zt2]], [[3zt3|3zt3]], [[3zt4|3zt4]], [[3zsw|3zsw]], [[1hyz|1hyz]], [[3zso|3zso]], [[1hyv|1hyv]], [[3zsx|3zsx]], [[3zsz|3zsz]], [[3zt0|3zt0]], [[3zsv|3zsv]], [[3zsy|3zsy]], [[3zsr|3zsr]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zsq|3zsq]], [[3zt2|3zt2]], [[3zt3|3zt3]], [[3zt4|3zt4]], [[3zsw|3zsw]], [[1hyz|1hyz]], [[3zso|3zso]], [[1hyv|1hyv]], [[3zsx|3zsx]], [[3zsz|3zsz]], [[3zt0|3zt0]], [[3zsv|3zsv]], [[3zsy|3zsy]], [[3zsr|3zsr]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zt1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zt1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zt1 RCSB], [http://www.ebi.ac.uk/pdbsum/3zt1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.,Peat TS, Rhodes DI, Vandegraaff N, Le G, Smith JA, Clark LJ, Jones ED, Coates JA, Thienthong N, Newman J, Dolezal O, Mulder R, Ryan JH, Savage GP, Francis CL, Deadman JJ PLoS One. 2012;7(7):e40147. Epub 2012 Jul 10. PMID:22808106<ref>PMID:22808106</ref> | Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.,Peat TS, Rhodes DI, Vandegraaff N, Le G, Smith JA, Clark LJ, Jones ED, Coates JA, Thienthong N, Newman J, Dolezal O, Mulder R, Ryan JH, Savage GP, Francis CL, Deadman JJ PLoS One. 2012;7(7):e40147. Epub 2012 Jul 10. PMID:22808106<ref>PMID:22808106</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human immunodeficiency virus]] | [[Category: Human immunodeficiency virus]] | ||
| - | [[Category: Coates, J A.V | + | [[Category: Coates, J A.V]] |
| - | [[Category: Deadman, J J | + | [[Category: Deadman, J J]] |
| - | [[Category: Dolezal, O | + | [[Category: Dolezal, O]] |
| - | [[Category: Francis, C L | + | [[Category: Francis, C L]] |
| - | [[Category: Jones, E D | + | [[Category: Jones, E D]] |
| - | [[Category: Le, G | + | [[Category: Le, G]] |
| - | [[Category: Newman, J | + | [[Category: Newman, J]] |
| - | [[Category: Peat, T S | + | [[Category: Peat, T S]] |
| - | [[Category: Rhodes, D I | + | [[Category: Rhodes, D I]] |
| - | [[Category: Ryan, J H | + | [[Category: Ryan, J H]] |
| - | [[Category: Savage, G P | + | [[Category: Savage, G P]] |
| - | [[Category: Smith, J A | + | [[Category: Smith, J A]] |
| - | [[Category: Thienthong, N | + | [[Category: Thienthong, N]] |
| - | [[Category: Vandergraaff, N | + | [[Category: Vandergraaff, N]] |
[[Category: Aid]] | [[Category: Aid]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 09:12, 4 January 2015
Small molecule inhibitors of the LEDGF site of HIV type 1 integrase identified by fragment screening and structure based drug design
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