4a32
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4a32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A32 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4a32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A32 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CD:3,5-DICHLORO-3-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE'>2CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CD:3,5-DICHLORO-3-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE'>2CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a33|4a33]], [[4a30|4a30]], [[2wsa|2wsa]], [[4a2z|4a2z]], [[4a31|4a31]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a33|4a33]], [[4a30|4a30]], [[2wsa|2wsa]], [[4a2z|4a2z]], [[4a31|4a31]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a32 RCSB], [http://www.ebi.ac.uk/pdbsum/4a32 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a32 RCSB], [http://www.ebi.ac.uk/pdbsum/4a32 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754<ref>PMID:22148754</ref> | Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754<ref>PMID:22148754</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Glycylpeptide N-tetradecanoyltransferase]] | [[Category: Glycylpeptide N-tetradecanoyltransferase]] | ||
[[Category: Leishmania major]] | [[Category: Leishmania major]] | ||
| - | [[Category: Brand, S | + | [[Category: Brand, S]] |
| - | [[Category: Brenk, R | + | [[Category: Brenk, R]] |
| - | [[Category: Cleghorn, L A.T | + | [[Category: Cleghorn, L A.T]] |
| - | [[Category: Fairlamb, A H | + | [[Category: Fairlamb, A H]] |
| - | [[Category: Ferguson, M A.J | + | [[Category: Ferguson, M A.J]] |
| - | [[Category: Frearson, J A | + | [[Category: Frearson, J A]] |
| - | [[Category: Gilbert, I H | + | [[Category: Gilbert, I H]] |
| - | [[Category: Hallyburton, I | + | [[Category: Hallyburton, I]] |
| - | [[Category: Harrison, J R | + | [[Category: Harrison, J R]] |
| - | [[Category: Mcelroy, S P | + | [[Category: Mcelroy, S P]] |
| - | [[Category: Norcross, N R | + | [[Category: Norcross, N R]] |
| - | [[Category: Norval, S | + | [[Category: Norval, S]] |
| - | [[Category: Read, K D | + | [[Category: Read, K D]] |
| - | [[Category: Robinson, D A | + | [[Category: Robinson, D A]] |
| - | [[Category: Smith, V C | + | [[Category: Smith, V C]] |
| - | [[Category: Spinks, D | + | [[Category: Spinks, D]] |
| - | [[Category: Stojanovski, L | + | [[Category: Stojanovski, L]] |
| - | [[Category: Torrie, L S | + | [[Category: Torrie, L S]] |
| - | [[Category: Wyatt, P G | + | [[Category: Wyatt, P G]] |
[[Category: Acyltransferase]] | [[Category: Acyltransferase]] | ||
[[Category: Drug discovery]] | [[Category: Drug discovery]] | ||
[[Category: Leishmaniasis]] | [[Category: Leishmaniasis]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:41, 25 December 2014
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
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Categories: Glycylpeptide N-tetradecanoyltransferase | Leishmania major | Brand, S | Brenk, R | Cleghorn, L A.T | Fairlamb, A H | Ferguson, M A.J | Frearson, J A | Gilbert, I H | Hallyburton, I | Harrison, J R | Mcelroy, S P | Norcross, N R | Norval, S | Read, K D | Robinson, D A | Smith, V C | Spinks, D | Stojanovski, L | Torrie, L S | Wyatt, P G | Acyltransferase | Drug discovery | Leishmaniasis | Transferase
