4aj5
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4aj5]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJ5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4aj5]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJ5 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aj5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aj5 RCSB], [http://www.ebi.ac.uk/pdbsum/4aj5 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aj5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aj5 RCSB], [http://www.ebi.ac.uk/pdbsum/4aj5 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SKA3_HUMAN SKA3_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization.<ref>PMID:19289083</ref> <ref>PMID:19360002</ref> [[http://www.uniprot.org/uniprot/SKA2_HUMAN SKA2_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.<ref>PMID:17093495</ref> <ref>PMID:19289083</ref> [[http://www.uniprot.org/uniprot/SKA1_HUMAN SKA1_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.<ref>PMID:17093495</ref> <ref>PMID:19289083</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Benda, C | + | [[Category: Benda, C]] |
| - | [[Category: Chan, Y W | + | [[Category: Chan, Y W]] |
| - | [[Category: Conti, E | + | [[Category: Conti, E]] |
| - | [[Category: Jayachandran, U | + | [[Category: Jayachandran, U]] |
| - | [[Category: Jeyaprakash, A A | + | [[Category: Jeyaprakash, A A]] |
| - | [[Category: Nigg, E A | + | [[Category: Nigg, E A]] |
| - | [[Category: Santamaria, A | + | [[Category: Santamaria, A]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cell division]] | [[Category: Cell division]] | ||
Revision as of 17:45, 25 December 2014
Crystal structure of the Ska core complex
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