1bar

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bar OCA], [http://www.ebi.ac.uk/pdbsum/1bar PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bar RCSB]</span>
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[[Category: growth factor]]
[[Category: growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:08:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:57:19 2008''

Revision as of 15:57, 30 March 2008

Image:1bar.jpg


PDB ID 1bar

Drag the structure with the mouse to rotate
, resolution 2.7Å
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



THREE-DIMENSIONAL STRUCTURES OF ACIDIC AND BASIC FIBROBLAST GROWTH FACTORS


Overview

Members of the fibroblast growth factor (FGF) family of proteins stimulate the proliferation and differentiation of a variety of cell types through receptor-mediated pathways. The three-dimensional structures of two members of this family, bovine acidic FGF and human basic FGF, have been crystallographically determined. These structures contain 12 antiparallel beta strands organized into a folding pattern with approximate threefold internal symmetry. Topologically equivalent folds have been previously observed for soybean trypsin inhibitor and interleukins-1 beta and -1 alpha. The locations of sequences implicated in receptor and heparin binding by FGF are presented. These sites include beta-sheet strand 10, which is adjacent to the site of an extended sequence insertion in several oncogene proteins of the FGF family, and which shows sequence conservation among the FGF family and interleukin-1 beta.

About this Structure

1BAR is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structures of acidic and basic fibroblast growth factors., Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC, Science. 1991 Jan 4;251(4989):90-3. PMID:1702556

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