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4ae7

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ae7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AE7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ae7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AE7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ae8|4ae8]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ae8|4ae8]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ae7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ae7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ae7 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ae7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ae7 RCSB], [http://www.ebi.ac.uk/pdbsum/4ae7 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/THEM5_HUMAN THEM5_HUMAN]] Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.<ref>PMID:22586271</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bleck, C K.E.]]
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[[Category: Bleck, C K.E]]
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[[Category: Cron, P.]]
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[[Category: Cron, P]]
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[[Category: Dummler, B.]]
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[[Category: Dummler, B]]
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[[Category: Esposti, M Degli.]]
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[[Category: Esposti, M Degli]]
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[[Category: Genoud, C.]]
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[[Category: Genoud, C]]
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[[Category: Gut, H.]]
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[[Category: Gut, H]]
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[[Category: Hemmings, B A.]]
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[[Category: Hemmings, B A]]
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[[Category: Hynx, D.]]
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[[Category: Hynx, D]]
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[[Category: Keusch, J J.]]
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[[Category: Keusch, J J]]
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[[Category: Marcellin, D.]]
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[[Category: Marcellin, D]]
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[[Category: Zhuravleva, E.]]
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[[Category: Zhuravleva, E]]
[[Category: Hotdog-fold]]
[[Category: Hotdog-fold]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 14:24, 25 December 2014

Crystal structure of human THEM5

4ae7, resolution 1.45Å

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