This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4am0
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4am0]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AM0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4am0]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus Dengue virus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AM0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4al8|4al8]], [[4ala|4ala]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4al8|4al8]], [[4ala|4ala]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4am0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4am0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4am0 RCSB], [http://www.ebi.ac.uk/pdbsum/4am0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4am0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4am0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4am0 RCSB], [http://www.ebi.ac.uk/pdbsum/4am0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q7TGC6_9FLAV Q7TGC6_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 22: | ||
[[Category: Dengue virus]] | [[Category: Dengue virus]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Flanagan, A | + | [[Category: Flanagan, A]] |
| - | [[Category: Grimes, J M | + | [[Category: Grimes, J M]] |
| - | [[Category: Midgley, C M | + | [[Category: Midgley, C M]] |
| - | [[Category: Mongkolsapaya, J | + | [[Category: Mongkolsapaya, J]] |
| - | [[Category: Screaton, G R | + | [[Category: Screaton, G R]] |
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Neutralisation]] | [[Category: Neutralisation]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 19:20, 25 December 2014
Structure of Dengue virus strain 4 DIII in complex with Fab 2H12
| |||||||||||
