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4cr0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/vietnam/1194/2004(h5n1)) Influenza a virus (a/vietnam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CR0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cr0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/vietnam/1194/2004(h5n1)) Influenza a virus (a/vietnam/1194/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CR0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqs|4cqs]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqw|4cqw]], [[4cqx|4cqx]], [[4cqy|4cqy]], [[4cqz|4cqz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqs|4cqs]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqw|4cqw]], [[4cqx|4cqx]], [[4cqy|4cqy]], [[4cqz|4cqz]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cr0 RCSB], [http://www.ebi.ac.uk/pdbsum/4cr0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cr0 RCSB], [http://www.ebi.ac.uk/pdbsum/4cr0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Collins, P J | + | [[Category: Collins, P J]] |
| - | [[Category: Coombs, P J | + | [[Category: Coombs, P J]] |
| - | [[Category: Gamblin, S J | + | [[Category: Gamblin, S J]] |
| - | [[Category: Lin, Y P | + | [[Category: Lin, Y P]] |
| - | [[Category: Liu, J | + | [[Category: Liu, J]] |
| - | [[Category: Martin, S R | + | [[Category: Martin, S R]] |
| - | [[Category: McCauley, J W | + | [[Category: McCauley, J W]] |
| - | [[Category: Skehel, J J | + | [[Category: Skehel, J J]] |
| - | [[Category: Vachieri, S G | + | [[Category: Vachieri, S G]] |
| - | [[Category: Walker, P A | + | [[Category: Walker, P A]] |
| - | [[Category: Xiao, H | + | [[Category: Xiao, H]] |
| - | [[Category: Xiong, X | + | [[Category: Xiong, X]] |
[[Category: 3'sln]] | [[Category: 3'sln]] | ||
| - | [[Category: 3sln]] | ||
[[Category: 6'sln]] | [[Category: 6'sln]] | ||
| - | [[Category: 6sln]] | ||
[[Category: Avian flu]] | [[Category: Avian flu]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
Revision as of 15:24, 25 December 2014
Crystal Structure of H5 (VN1194) Asn186Lys/Gly143Arg Mutant Haemagglutinin
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Categories: Collins, P J | Coombs, P J | Gamblin, S J | Lin, Y P | Liu, J | Martin, S R | McCauley, J W | Skehel, J J | Vachieri, S G | Walker, P A | Xiao, H | Xiong, X | 3'sln | 6'sln | Avian flu | Glycoprotein | Lsta | Sialic acid | Sialyllactosamine | Viral protein | Virus receptor
