4tmp
From Proteopedia
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| - | ''' | + | ==Crystal structure of AF9 YEATS bound to H3K9ac peptide== |
| - | + | <StructureSection load='4tmp' size='340' side='right' caption='[[4tmp]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4tmp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TMP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tmp RCSB], [http://www.ebi.ac.uk/pdbsum/4tmp PDBsum]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN]] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Li, H.]] | ||
| + | [[Category: Li, Y.]] | ||
| + | [[Category: Ren, Y.]] | ||
| + | [[Category: Wang, H.]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Histone modification]] | ||
| + | [[Category: Immunoglobin fold]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 09:02, 5 November 2014
Crystal structure of AF9 YEATS bound to H3K9ac peptide
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