1bqu
From Proteopedia
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|PDB= 1bqu |SIZE=350|CAPTION= <scene name='initialview01'>1bqu</scene>, resolution 2.00Å | |PDB= 1bqu |SIZE=350|CAPTION= <scene name='initialview01'>1bqu</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= IL6ST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= IL6ST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqu OCA], [http://www.ebi.ac.uk/pdbsum/1bqu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bqu RCSB]</span> | ||
}} | }} | ||
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[[Category: Jones, E Y.]] | [[Category: Jones, E Y.]] | ||
[[Category: Staunton, D.]] | [[Category: Staunton, D.]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: SO4]] | ||
[[Category: cytokine receptor]] | [[Category: cytokine receptor]] | ||
[[Category: glycoprotein 130]] | [[Category: glycoprotein 130]] | ||
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[[Category: interleukine 6 receptor beta subunit]] | [[Category: interleukine 6 receptor beta subunit]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:06:22 2008'' |
Revision as of 16:06, 30 March 2008
| |||||||
| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | IL6ST (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CYTOKYNE-BINDING REGION OF GP130
Overview
The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.
About this Structure
1BQU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:9501088
Page seeded by OCA on Sun Mar 30 19:06:22 2008
