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4l5c
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l5c]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L5C FirstGlance]. <br> | <table><tr><td colspan='2'>[[4l5c]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L5C FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l5a|4l5a]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l5a|4l5a]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l5c RCSB], [http://www.ebi.ac.uk/pdbsum/4l5c PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l5c RCSB], [http://www.ebi.ac.uk/pdbsum/4l5c PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/I0B503_SCHMA I0B503_SCHMA]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates (By similarity).[HAMAP-Rule:MF_03155] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[5'-deoxy-5'-methylthioadenosine phosphorylase|5'-deoxy-5'-methylthioadenosine phosphorylase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: S-methyl-5'-thioadenosine phosphorylase]] | [[Category: S-methyl-5'-thioadenosine phosphorylase]] | ||
| - | [[Category: Brandao-Neto, J | + | [[Category: Brandao-Neto, J]] |
| - | [[Category: DeMarco, R | + | [[Category: DeMarco, R]] |
| - | [[Category: Pereira, H M | + | [[Category: Pereira, H M]] |
| - | [[Category: Torini, J R | + | [[Category: Torini, J R]] |
[[Category: Enzyme]] | [[Category: Enzyme]] | ||
[[Category: Nucleoside phosphorylase]] | [[Category: Nucleoside phosphorylase]] | ||
[[Category: Phsophorylase]] | [[Category: Phsophorylase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 20:33, 24 December 2014
Methylthioadenosine phosphorylase from Schistosoma mansoni in complex with adenine in space group P212121
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