1bsx

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|PDB= 1bsx |SIZE=350|CAPTION= <scene name='initialview01'>1bsx</scene>, resolution 3.7&Aring;
|PDB= 1bsx |SIZE=350|CAPTION= <scene name='initialview01'>1bsx</scene>, resolution 3.7&Aring;
|SITE= <scene name='pdbsite=A:Nr-Box+Binding+Site'>A</scene> and <scene name='pdbsite=B:Nr-Box+Binding+Site'>B</scene>
|SITE= <scene name='pdbsite=A:Nr-Box+Binding+Site'>A</scene> and <scene name='pdbsite=B:Nr-Box+Binding+Site'>B</scene>
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|LIGAND= <scene name='pdbligand=T3:3,5,3'TRIIODOTHYRONINE'>T3</scene>
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|LIGAND= <scene name='pdbligand=T3:3,5,3&#39;TRIIODOTHYRONINE'>T3</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: specificity interaction site]]
[[Category: specificity interaction site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:15:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:17:28 2008''

Revision as of 09:17, 23 March 2008

Image:1bsx.gif


PDB ID 1bsx

Drag the structure with the mouse to rotate
, resolution 3.7Å
Sites: and
Ligands:
Coordinates: save as pdb, mmCIF, xml



STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS


Contents

Overview

Combinatorial regulation of transcription implies flexible yet precise assembly of multiprotein regulatory complexes in response to signals. Biochemical and crystallographic analyses revealed that hormone binding leads to the formation of a hydrophobic groove within the ligand binding domain (LBD) of the thyroid hormone receptor that interacts with an LxxLL motif-containing alpha-helix from GRIP1, a coactivator. Residues immediately adjacent to the motif modulate the affinity of the interaction; the motif and the adjacent sequences are employed to different extents in binding to different receptors. Such interactions of amphipathic alpha-helices with hydrophobic grooves define protein interfaces in other regulatory complexes as well. We suggest that these common structural elements impart flexibility to combinatorial regulation, whereas side chains at the interface impart specificity.

Disease

Known diseases associated with this structure: Thyroid hormone resistance OMIM:[190160], Thyroid hormone resistance, autosomal recessive OMIM:[190160]

About this Structure

1BSX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and specificity of nuclear receptor-coactivator interactions., Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR, Genes Dev. 1998 Nov 1;12(21):3343-56. PMID:9808622

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