This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3ue8
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UE8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UE8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADAT, KAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADAT, KAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ue8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ue8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Anderson, M | + | [[Category: Anderson, M]] |
| - | [[Category: Bechle, B M | + | [[Category: Bechle, B M]] |
| - | [[Category: Campbell, B M | + | [[Category: Campbell, B M]] |
| - | [[Category: Claffey, M M | + | [[Category: Claffey, M M]] |
| - | [[Category: Dounay, A B | + | [[Category: Dounay, A B]] |
| - | [[Category: Edelweiss, E | + | [[Category: Edelweiss, E]] |
| - | [[Category: Evdokimov, A | + | [[Category: Evdokimov, A]] |
| - | [[Category: Fonseca, K R | + | [[Category: Fonseca, K R]] |
| - | [[Category: Gan, X | + | [[Category: Gan, X]] |
| - | [[Category: Ghosh, S | + | [[Category: Ghosh, S]] |
| - | [[Category: Hayward, M M | + | [[Category: Hayward, M M]] |
| - | [[Category: Horner, W | + | [[Category: Horner, W]] |
| - | [[Category: Kim, J Y | + | [[Category: Kim, J Y]] |
| - | [[Category: McAllister, L A | + | [[Category: McAllister, L A]] |
| - | [[Category: Pandit, J | + | [[Category: Pandit, J]] |
| - | [[Category: Paradis, V | + | [[Category: Paradis, V]] |
| - | [[Category: Parikh, V D | + | [[Category: Parikh, V D]] |
| - | [[Category: Reese, M R | + | [[Category: Reese, M R]] |
| - | [[Category: Rong, S B | + | [[Category: Rong, S B]] |
| - | [[Category: Salafia, M A | + | [[Category: Salafia, M A]] |
| - | [[Category: Schuyten, K | + | [[Category: Schuyten, K]] |
| - | [[Category: Strick, C A | + | [[Category: Strick, C A]] |
| - | [[Category: Tuttle, J B | + | [[Category: Tuttle, J B]] |
| - | [[Category: Valentine, J | + | [[Category: Valentine, J]] |
| - | [[Category: Verhoest, P R | + | [[Category: Verhoest, P R]] |
| - | [[Category: Wang, H | + | [[Category: Wang, H]] |
| - | [[Category: Zawadzke, L E | + | [[Category: Zawadzke, L E]] |
[[Category: Kat ii]] | [[Category: Kat ii]] | ||
[[Category: Kynurenine aminotransferase]] | [[Category: Kynurenine aminotransferase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 20:34, 24 December 2014
Kynurenine Aminotransferase II Inhibitors
| |||||||||||
Categories: Homo sapiens | Anderson, M | Bechle, B M | Campbell, B M | Claffey, M M | Dounay, A B | Edelweiss, E | Evdokimov, A | Fonseca, K R | Gan, X | Ghosh, S | Hayward, M M | Horner, W | Kim, J Y | McAllister, L A | Pandit, J | Paradis, V | Parikh, V D | Reese, M R | Rong, S B | Salafia, M A | Schuyten, K | Strick, C A | Tuttle, J B | Valentine, J | Verhoest, P R | Wang, H | Zawadzke, L E | Kat ii | Kynurenine aminotransferase | Transferase-transferase inhibitor complex
