3ue8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UE8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UE8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADAT, KAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADAT, KAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ue8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ue8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Anderson, M | + | [[Category: Anderson, M]] |
| - | [[Category: Bechle, B M | + | [[Category: Bechle, B M]] |
| - | [[Category: Campbell, B M | + | [[Category: Campbell, B M]] |
| - | [[Category: Claffey, M M | + | [[Category: Claffey, M M]] |
| - | [[Category: Dounay, A B | + | [[Category: Dounay, A B]] |
| - | [[Category: Edelweiss, E | + | [[Category: Edelweiss, E]] |
| - | [[Category: Evdokimov, A | + | [[Category: Evdokimov, A]] |
| - | [[Category: Fonseca, K R | + | [[Category: Fonseca, K R]] |
| - | [[Category: Gan, X | + | [[Category: Gan, X]] |
| - | [[Category: Ghosh, S | + | [[Category: Ghosh, S]] |
| - | [[Category: Hayward, M M | + | [[Category: Hayward, M M]] |
| - | [[Category: Horner, W | + | [[Category: Horner, W]] |
| - | [[Category: Kim, J Y | + | [[Category: Kim, J Y]] |
| - | [[Category: McAllister, L A | + | [[Category: McAllister, L A]] |
| - | [[Category: Pandit, J | + | [[Category: Pandit, J]] |
| - | [[Category: Paradis, V | + | [[Category: Paradis, V]] |
| - | [[Category: Parikh, V D | + | [[Category: Parikh, V D]] |
| - | [[Category: Reese, M R | + | [[Category: Reese, M R]] |
| - | [[Category: Rong, S B | + | [[Category: Rong, S B]] |
| - | [[Category: Salafia, M A | + | [[Category: Salafia, M A]] |
| - | [[Category: Schuyten, K | + | [[Category: Schuyten, K]] |
| - | [[Category: Strick, C A | + | [[Category: Strick, C A]] |
| - | [[Category: Tuttle, J B | + | [[Category: Tuttle, J B]] |
| - | [[Category: Valentine, J | + | [[Category: Valentine, J]] |
| - | [[Category: Verhoest, P R | + | [[Category: Verhoest, P R]] |
| - | [[Category: Wang, H | + | [[Category: Wang, H]] |
| - | [[Category: Zawadzke, L E | + | [[Category: Zawadzke, L E]] |
[[Category: Kat ii]] | [[Category: Kat ii]] | ||
[[Category: Kynurenine aminotransferase]] | [[Category: Kynurenine aminotransferase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 20:34, 24 December 2014
Kynurenine Aminotransferase II Inhibitors
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Categories: Homo sapiens | Anderson, M | Bechle, B M | Campbell, B M | Claffey, M M | Dounay, A B | Edelweiss, E | Evdokimov, A | Fonseca, K R | Gan, X | Ghosh, S | Hayward, M M | Horner, W | Kim, J Y | McAllister, L A | Pandit, J | Paradis, V | Parikh, V D | Reese, M R | Rong, S B | Salafia, M A | Schuyten, K | Strick, C A | Tuttle, J B | Valentine, J | Verhoest, P R | Wang, H | Zawadzke, L E | Kat ii | Kynurenine aminotransferase | Transferase-transferase inhibitor complex
