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Ribonucleotide reductase
From Proteopedia
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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }} | {{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }} | ||
| - | '''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. | + | '''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.<br /> |
| + | * '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.<br /> | ||
| + | * ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br /> | ||
| + | * '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center.<br /> | ||
| + | For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]]. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
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[[4n82]] – SsRNR – ''Streptococcus sanguinis''<br /> | [[4n82]] – SsRNR – ''Streptococcus sanguinis''<br /> | ||
| - | + | ''RNR large subunit complex'' | |
[[3hnc]] – hRNR M1 + TTP – human<BR /> | [[3hnc]] – hRNR M1 + TTP – human<BR /> | ||
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[[4n83]] - SsRNR + Mn<br /> | [[4n83]] - SsRNR + Mn<br /> | ||
| - | + | ''RNR small subunit complex'' | |
[[1rsr]], [[1rsv]] - EcRNR R2 (mutant) + N3<BR /> | [[1rsr]], [[1rsv]] - EcRNR R2 (mutant) + N3<BR /> | ||
Revision as of 08:33, 20 August 2014
Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.
- Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.
- Class II RNR reduces ribonucleotide triphosphates using coenzyme B12.
- Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center.
For details on human RNR2 see P53R2. For mouse RNR see Mouse Ribonucleotide Reductase R2.
Contents |
3D Structures of Ribonucleotide reductase
Updated on 20-August-2014
Class I RNR
RNR large subunit
1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
5r1r, 6r1r, 7r1r, 1r1r, 1rlr, 1mrr - EcRNR R1 – Escherichia coli
4n82 – SsRNR – Streptococcus sanguinis
RNR large subunit complex
3hnc – hRNR M1 + TTP – human
3hnd – hRNR M1 + GDP + TTP
3hne, 3hnf – hRNR M1 + ATP + TTP
2wgh - hRNR M1 + ATP + Mg
3paw - yRNR R1 + ATP
3k8t - yRNR R1 + ADP analog
3s87 - yRNR R1 + ADP + GTP
3s8a - yRNR R1 (mutant) + GTP
3tba - yRNR R1 (mutant) + GTP + ADP
3s8b - yRNR R1 + AMPPNP + CDP
3s8c, 3tb9 - yRNR R1 (mutant) + AMPPNP + CDP
2zlf, 2zlg - yRNR R1 + peptide
2eud - yRNR R1 + ligand
3rsr – yRNR + inhibitor
2r1r - EcRNR R1 + TTP
3r1r - EcRNR R1 + AMPPNP
4r1r - EcRNR R1 + GDP + TTP
1qfn - EcRNR R1 + glutaredoxin 1
1peu - StRNR + DTP - Salmonella typhimurium
RNR small subunit
2xof, 3n37, 3n38, 2alx, 1piy, 1r65, 1mxr, 1jqc, 1jpr, 1av8, 1xik, 1rib, 4m1f – EcRNR R2
1yfd, 1piz, 1pj0, 1pj1, 1pm2, 1pim, 1piu, 1biq, 2av8, 1pfr - EcRNR R2 (mutant)
3hf1, 2vux, 2uw2, 4djn – hRNR M2
3mjo, 3dhz, 1oqu, 1kgn, 1kgo, 1kgp – RNR R2 – Corynebacterium ammoniagenes
2p1i – RNR R2 – Plasmodium yoelii
2o1z - RNR R2 – Plasmodium vivax
1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
1smq, 1sms – yRNR 2
4d8f, 4d8g, 4m1i - CtRNR R2 + Fe + Mn
1syy - CtRNR R2 + Fe + Pb– Chlamydia trachomatis
2ani - CtRNR R2 (mutant) + Fe + Pb
4m1h - CtRNR R2
4dr0 - RNR + Mn – Bacillus subtilis
1uzr – RNR R2 – Mycobacterium tuberculosis
3olj – hRNR M2
1jk0 – yRNR Y2+Y4
3vpm, 3vpn, 3vpo – hRNR M2 (mutant)
2rcc – RNR – Bacillus halodurans
4bmq, 4bmr, 4bmt - BcRNR + Fe – Bacillus cereus
4bmu - BcRNR + Mn
4n83 - SsRNR + Mn
RNR small subunit complex
1rsr, 1rsv - EcRNR R2 (mutant) + N3
3n39, 3n3a, 3n3b – EcRNR R2 + NrdI
1rnr – EcRNR R2 (mutant) + dopa
1w69 – mRNR R2 + acetate
4bmo, 4bmp - BcRNR + NRDI
RNR small+large subunit
3uus, 4erm - EcRNR R1+ R2
4erp - EcRNR R1+ R2 + inhibitor
2xak, 2xap, 2xo4, 2xo5 - EcRNR R1+ R2 peptide
2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) + R2 peptide
2bq1 - StRNR R1+ R2
Class II RNR
1xjf – TmRNR + ATP – Thermotoga maritima
1xjg - TmRNR + ATP-UDP
1xjj - TmRNR + GTP
1xjk - TmRNR + GTP-ADP
1xjm - TmRNR + TTP
1xje - TmRNR + TTP-GDP
1xjn - TmRNR + ATP-CDP
3o0n - TmRNR + TTP + Co + Mg + deoxyadenosine + B12
3o0o - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12
3o0q - TmRNR + TTP + GDP + Mg + adenosine
1pem - StRNR R1
1r2f, 2r2f - StRNR R2
1peo, 1peq, 2peu - StRNR R1 + effector
1l1l – RNR (mutant) – Lactobacillus leichmannii
Class III RNR
1h78, 1h79, 1h7a, 1hk8 – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4
1h7b – T4RNR (mutant)
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