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4gos
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br> | <table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN]] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Almo, S C | + | [[Category: Almo, S C]] |
| - | [[Category: Bhosle, R | + | [[Category: Bhosle, R]] |
| - | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network | + | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Nathenson, S G | + | [[Category: Nathenson, S G]] |
| - | [[Category: Ramagopal, U | + | [[Category: Ramagopal, U]] |
| - | [[Category: Toro, R | + | [[Category: Toro, R]] |
| - | [[Category: Vigdorovich, V | + | [[Category: Vigdorovich, V]] |
[[Category: Adaptive immunity]] | [[Category: Adaptive immunity]] | ||
[[Category: Cell surface]] | [[Category: Cell surface]] | ||
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[[Category: Immunoglobulin domain]] | [[Category: Immunoglobulin domain]] | ||
[[Category: Immunoglobulin variable-like domain]] | [[Category: Immunoglobulin variable-like domain]] | ||
| - | [[Category: New york structural genomics research consortium]] | ||
[[Category: Nysgrc]] | [[Category: Nysgrc]] | ||
| - | [[Category: Protein structure initiative]] | + | [[Category: PSI, Protein structure initiative]] |
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
| - | [[Category: Structural genomic]] | ||
Revision as of 16:31, 24 December 2014
Crystal structure of human B7-H4 IgV-like domain
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Categories: Homo sapiens | Almo, S C | Bhosle, R | IFN, Atoms-to-Animals:.The Immune Function Network | Structural genomic | Nathenson, S G | Ramagopal, U | Toro, R | Vigdorovich, V | Adaptive immunity | Cell surface | Disulfide bond | Glycoprotein | Immune system | Immunity | Immunoglobulin domain | Immunoglobulin variable-like domain | Nysgrc | PSI, Protein structure initiative | Psi-biology
