Aspartate decarboxylase

Function

Aspartate decarboxylase (ADC) catalyzes the conversion of L-aspartate to β-alanine and CO2. ADC is a pyruvate-dependent enzyme which is synthesized as an inactive protein. The ADC precursor is cleaved to the active α and β subunits.

Disease

Relevance

Structural highlights

3D structures of aspartate decarboxylase

Updated on 25-August-2014

Aspartate decarboxylase

1aw8, 1pt0, 1pyq – EcADC – Escherichia coli
1pt1, 1pqe, 1pqf, 1pqh, 1pyu, 3tm7, 4azd – EcADC (mutant)
1ppy – EcADC precursor
1vc3 – TtADC – Thermus thermophilus
2c45 – ADC – Mycobacterium tuberculosis
3oug – ADC – Francesella tularensis
3plx – ADC – Campylobacter jejuni

Aspartate decarboxylase complexes

1uhd – HpADC + pyruvate – Helicobacter pylori
1uhe – HpADC + isoasparagine
2eeo – TtADC + pyruvate + fumarate
4aok, 4aon – EcADC + methyl aspartate derivative

References