4uq3

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m (Protected "4uq3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of HLA-A0201 in complex with an azobenzene- containing peptide==
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<StructureSection load='4uq3' size='340' side='right' caption='[[4uq3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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The entry 4uq3 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4uq3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UQ3 FirstGlance]. <br>
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Authors: Thong, S.Y., Yap, J.W., Lim, P.Y., Verhelst, S.H., Lescar, J., Meijers, R., Grotenbreg, G.M.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=XFW:(2S)-2,5,5-TRIS(AZANYL)PENTANOIC+ACID'>XFW</scene>, <scene name='pdbligand=XY1:4-[(E)-[5-(2-AZANYLETHYL)-2-OXIDANYL-PHENYL]DIAZENYL]BENZOIC+ACID'>XY1</scene></td></tr>
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Description: Crystal structure of HLA-A0201 in complex with an azobenzene-containing peptide
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uq2|4uq2]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uq3 RCSB], [http://www.ebi.ac.uk/pdbsum/4uq3 PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Grotenbreg, G M]]
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[[Category: Lescar, J]]
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[[Category: Lim, P Y]]
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[[Category: Meijers, R]]
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[[Category: Thong, S Y]]
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[[Category: Verhelst, S H]]
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[[Category: Yap, J W]]
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[[Category: Azobenzene]]
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[[Category: Hla-a]]
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[[Category: Immune system]]
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[[Category: Synthetic peptide]]

Revision as of 08:56, 5 January 2015

Crystal structure of HLA-A0201 in complex with an azobenzene- containing peptide

4uq3, resolution 2.10Å

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