4lgs
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lgs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LGS FirstGlance]. <br> | <table><tr><td colspan='2'>[[4lgs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LGS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LGS FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lgp|4lgp]], [[4lgr|4lgr]], [[4lhj|4lhj]], [[4lhq|4lhq]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lgp|4lgp]], [[4lgr|4lgr]], [[4lhj|4lhj]], [[4lhq|4lhq]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lgs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lgs RCSB], [http://www.ebi.ac.uk/pdbsum/4lgs PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lgs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lgs RCSB], [http://www.ebi.ac.uk/pdbsum/4lgs PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: RRNA N-glycosylase]] | [[Category: RRNA N-glycosylase]] | ||
| - | [[Category: Burshteyn, F | + | [[Category: Burshteyn, F]] |
| - | [[Category: Cassidy, M | + | [[Category: Cassidy, M]] |
| - | [[Category: Cheung, J | + | [[Category: Cheung, J]] |
| - | [[Category: Franklin, M | + | [[Category: Franklin, M]] |
| - | [[Category: Gary, E | + | [[Category: Gary, E]] |
| - | [[Category: Mantis, N | + | [[Category: Mantis, N]] |
| - | [[Category: Rudolph, M J | + | [[Category: Rudolph, M J]] |
[[Category: Hydrolase-immune system complex]] | [[Category: Hydrolase-immune system complex]] | ||
[[Category: Ribosomal inhibiting protein 2]] | [[Category: Ribosomal inhibiting protein 2]] | ||
Revision as of 11:44, 25 December 2014
Ricin A chain bound to camelid nanobody (VHH4)
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