1cbk
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1cbk |SIZE=350|CAPTION= <scene name='initialview01'>1cbk</scene>, resolution 2.02Å | |PDB= 1cbk |SIZE=350|CAPTION= <scene name='initialview01'>1cbk</scene>, resolution 2.02Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=ROI:7,8-DIHYDRO-7,7-DIMETHYL-6-HYDROXYPTERIN'>ROI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cbk OCA], [http://www.ebi.ac.uk/pdbsum/1cbk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cbk RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Hennig, M.]] | [[Category: Hennig, M.]] | ||
[[Category: Oefner, C.]] | [[Category: Oefner, C.]] | ||
| - | [[Category: ROI]] | ||
| - | [[Category: SO4]] | ||
[[Category: pyrophosphokinase]] | [[Category: pyrophosphokinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:18:26 2008'' |
Revision as of 16:18, 30 March 2008
| |||||||
| , resolution 2.02Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE FROM HAEMOPHILUS INFLUENZAE
Overview
The gene encoding the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase of Haemophilus influenzae has been cloned and expressed in Escherichia coli. A complex of the purified protein with a substrate analog has been crystallized and its structure solved by multiple anomalous dispersion using phase information obtained from a single crystal of selenomethione-labeled protein. The enzyme folds into a four-stranded antiparallel beta-sheet flanked on one side by two alpha-helices and on the other by three consecutive alpha-helices, giving a novel beta1alpha1beta2beta3alpha2beta4alpha3alpha4alpha5 polypeptide topology. The three-dimensional structure of a binary complex has been refined at 2.1 A resolution. The location of the substrate analog and a sulfate ion gives important insight into the molecular mechanism of the enzyme.
About this Structure
1CBK is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.
Reference
The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae., Hennig M, Dale GE, D'arcy A, Danel F, Fischer S, Gray CP, Jolidon S, Muller F, Page MG, Pattison P, Oefner C, J Mol Biol. 1999 Mar 26;287(2):211-9. PMID:10080886
Page seeded by OCA on Sun Mar 30 19:18:26 2008
