4tk4
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==GephE in complex with a GABA receptor alpha3 subunit derived double mutant peptide in space group P61== |
| - | + | <StructureSection load='4tk4' size='340' side='right' caption='[[4tk4]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4tk4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tk1|4tk1]], [[4tk2|4tk2]], [[4tk3|4tk3]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk4 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kasaragod, V B]] | ||
| + | [[Category: Maric, H M]] | ||
| + | [[Category: Schindelin, H]] | ||
| + | [[Category: Molybdenum co factor bio synthesis]] | ||
| + | [[Category: Neurotransmitter receptor anchoring]] | ||
| + | [[Category: Scaffolding protein]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 11:12, 24 December 2014
GephE in complex with a GABA receptor alpha3 subunit derived double mutant peptide in space group P61
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