1cdd
From Proteopedia
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|PDB= 1cdd |SIZE=350|CAPTION= <scene name='initialview01'>1cdd</scene>, resolution 2.8Å | |PDB= 1cdd |SIZE=350|CAPTION= <scene name='initialview01'>1cdd</scene>, resolution 2.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | + | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cdd OCA], [http://www.ebi.ac.uk/pdbsum/1cdd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cdd RCSB]</span> | ||
}} | }} | ||
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[[Category: Janson, C A.]] | [[Category: Janson, C A.]] | ||
[[Category: Kan, C C.]] | [[Category: Kan, C C.]] | ||
| - | [[Category: PO4]] | ||
[[Category: transferase(formyl)]] | [[Category: transferase(formyl)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:19:25 2008'' |
Revision as of 16:19, 30 March 2008
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| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Phosphoribosylglycinamide formyltransferase, with EC number 2.1.2.2 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
Overview
The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.
About this Structure
1CDD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:1631098
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