2mmt
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mmt]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MMT FirstGlance]. <br> | <table><tr><td colspan='2'>[[2mmt]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MMT FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mmt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mmt RCSB], [http://www.ebi.ac.uk/pdbsum/2mmt PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mmt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mmt RCSB], [http://www.ebi.ac.uk/pdbsum/2mmt PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MCJA_ECOLX MCJA_ECOLX]] Peptide antibiotic that functions through inhibition of the bacterial DNA-dependent RNA polymerase (RNAP). May inhibit transcription by binding in RNAP secondary channel and blocking nucleotide substrates access to the catalytic center. Exhibits potent bacteriocidal activity against a range of Enterobacteriaceae, including several pathogenic E.coli, Salmonella and Shigella strains. Also acts on the cytoplasmic membrane of Salmonella newport, producing alteration of membrane permeability and disruption of the subsequent gradient dissipation, which inhibits several processes essential for cell viability, such as oxygen consumption. Induces bacterial filamentation in susceptible cells in a non-SOS-dependent way, but this phenotype may result from impaired transcription of genes coding for cell division proteins.<ref>PMID:11731133</ref> <ref>PMID:11443089</ref> <ref>PMID:12401787</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Hegemann, J D | + | [[Category: Hegemann, J D]] |
| - | [[Category: Knappe, T A | + | [[Category: Knappe, T A]] |
| - | [[Category: Marahiel, M A | + | [[Category: Marahiel, M A]] |
| - | [[Category: Xie, X | + | [[Category: Xie, X]] |
| - | [[Category: Zimmermann, M | + | [[Category: Zimmermann, M]] |
[[Category: Antibiotic]] | [[Category: Antibiotic]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
Revision as of 00:27, 25 December 2014
Lasso peptide-based integrin inhibitor: Microcin J25 variant with RGDF substitution of Gly12-Ile13-Gly14-Thr15
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