Azurin

Function

Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.

Disease

Relevance

AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.

Structural highlights

3D structures of cAMP-dependent protein kinase

Updated on 08-July-2014

1e65 – PaAZ – Pseudomonas aeruginosa

Cu+2 containing azurin

1azu, 1azr, 4azu, 5azu, 1azn, 1cc3, 1e5y, 1e5z, 1jze, 2ft6, 2ft7, 2ft8, 2fta, 3fs9, 3fsa, 3fsv, 3fsw, 3fsz, 3ft0 – PaAZ
1joi – PfAZ – Pseudomonas fluorrescens
1nwo – PpAZ – Pseudomonas putida
1nwp – PpAZ + Zn+2
2aza, 1azb, 1azc – AxAZ – Achromobacter xylosoxidans
2azu, 3azu, 1ils, 1ilu, 2tsa, 2tsb, 1etj, 1ag0, 1ezl, 1jvo, 1gr7, 1xb3, 1xb6, 1xb8, 2ghz, 2hx7, 2oj1, 3in0, 3fpy, 3fq1, [3fq2]], 3fqy, 3in2, 3jt2, 3jtb, 3np3, 3np4, 3oqr, 3n2j, 3u25, 4hhw, 4mfh, 4ko5, 4ko6, 4ko7, 4ko9, 4kob, 4koc, 4bww – PaAZ (mutant)
1jvl, 2idf – PaAZ (mutant) + Ni+2
1uri, 1a4a, 1a4b, 1a4c – AdAZ (mutant)
2h3x, 2h47, 2iaa – AZ + aromatic amine dehydrogenase – Alcaligenes faecalis

Cu+2 containing lanthanide-modified azurin

1bex, 1jzi, 1jze, 1jzf, 1jzj, 1jsh – PaAZ
2i7s, 2fnw, 2i7o, 3ibo, 4hhg, 4k9j – PaAZ (mutant)

Cu+1 containing azurin

1jzg – PaAZ
1r1c, 2gi0, 1i53, 2hx8, 2hx9, 2hxa, 2xv0, 2xv2, 2xv3 – PaAZ (mutant)

Non-Cu+2 containing azurin

1aiz – AdAZ + Cd+2 – Achromobacter denitrificans
1nzr – PaAZ (mutant) + Ni+2
1vlx – PaAZ + Co+2
1e67 – PaAZ + Zn+2
2iwe – PaAZ (mutant) + Zn+2
3uge – PaAZ + Ag+1
4hz1 – PaAZ + Fe+2
4jkn – PaAZ + Hg+2

References