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4oyd
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4oyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYD FirstGlance]. <br> | <table><tr><td colspan='2'>[[4oyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYD FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyd RCSB], [http://www.ebi.ac.uk/pdbsum/4oyd PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyd RCSB], [http://www.ebi.ac.uk/pdbsum/4oyd PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EAR_EBVA8 EAR_EBVA8]] Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Baker, D | + | [[Category: Baker, D]] |
| - | [[Category: Procko, E | + | [[Category: Procko, E]] |
| - | [[Category: Shen, B | + | [[Category: Shen, B]] |
| - | [[Category: Stoddard, B | + | [[Category: Stoddard, B]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Complex]] | [[Category: Complex]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Viral protein-inhibitor complex]] | [[Category: Viral protein-inhibitor complex]] | ||
Revision as of 01:55, 25 December 2014
Crystal structure of a computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein
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