4o33

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'''Unreleased structure'''
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==Crystal Structure of human PGK1 3PG and terazosin(TZN) ternary complex==
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<StructureSection load='4o33' size='340' side='right' caption='[[4o33]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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The entry 4o33 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4o33]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O33 FirstGlance]. <br>
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Authors: Li, X.L., Finci, L.I., Wang, J.H.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=TZN:[4-(4-AMINO-6,7-DIMETHOXYQUINAZOLIN-2-YL)PIPERAZIN-1-YL][(2R)-TETRAHYDROFURAN-2-YL]METHANONE'>TZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o3f|4o3f]]</td></tr>
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Description: Crystal Structure of human PGK1 3PG and terazosin(TZN) ternary complex
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o33 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o33 RCSB], [http://www.ebi.ac.uk/pdbsum/4o33 PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[http://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Phosphoglycerate kinase]]
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[[Category: Finci, L I.]]
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[[Category: Li, X L.]]
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[[Category: Wang, J H.]]
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[[Category: Enzyme-drug complex]]
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[[Category: Transferase-transferase activator complex]]
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[[Category: Transferase-transferase activitor complex]]

Revision as of 11:27, 29 October 2014

Crystal Structure of human PGK1 3PG and terazosin(TZN) ternary complex

4o33, resolution 2.10Å

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