This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4txc
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4txc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXC FirstGlance]. <br> | <table><tr><td colspan='2'>[[4txc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38G:4-(3-{3-[(R)-{[2-(DIMETHYLAMINO)ETHYL]AMINO}(HYDROXY)METHYL]PHENYL}IMIDAZO[1,2-B]PYRIDAZIN-6-YL)-2-METHOXYPHENOL'>38G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38G:4-(3-{3-[(R)-{[2-(DIMETHYLAMINO)ETHYL]AMINO}(HYDROXY)METHYL]PHENYL}IMIDAZO[1,2-B]PYRIDAZIN-6-YL)-2-METHOXYPHENOL'>38G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yak|2yak]], [[4pf4|4pf4]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yak|2yak]], [[4pf4|4pf4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txc RCSB], [http://www.ebi.ac.uk/pdbsum/4txc PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txc RCSB], [http://www.ebi.ac.uk/pdbsum/4txc PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia. | ||
| + | |||
| + | Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1.,Wilbek TS, Skovgaard T, Sorrell FJ, Knapp S, Berthelsen J, Stromgaard K Chembiochem. 2014 Nov 7. doi: 10.1002/cbic.201402512. PMID:25382253<ref>PMID:25382253</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Berthelsen, J | + | [[Category: Berthelsen, J]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Chalk, R | + | [[Category: Chalk, R]] |
| - | [[Category: Delft, F Von | + | [[Category: Delft, F Von]] |
| - | [[Category: Dixon-Clarke, S | + | [[Category: Dixon-Clarke, S]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Knapp, S | + | [[Category: Knapp, S]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Skovgaard, T | + | [[Category: Skovgaard, T]] |
| - | [[Category: Sorrell, F J | + | [[Category: Sorrell, F J]] |
| - | [[Category: Stromgaard, K | + | [[Category: Stromgaard, K]] |
| - | [[Category: Wilbek, T S | + | [[Category: Wilbek, T S]] |
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
Revision as of 10:57, 19 November 2014
Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor
| |||||||||||
Categories: Non-specific serine/threonine protein kinase | Arrowsmith, C H | Berthelsen, J | Bountra, C | Chalk, R | Delft, F Von | Dixon-Clarke, S | Edwards, A M | Knapp, S | Krojer, T | Skovgaard, T | Sorrell, F J | Stromgaard, K | Wilbek, T S | Catalytic domain | Kinase | Protein binding | Protein kinase | Protein kinase inhibitor | Protein-ligand complex | Small-molecule | Transferase
