4lwi
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lwi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LWI FirstGlance]. <br> | <table><tr><td colspan='2'>[[4lwi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LWI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ6:N-{3-[2,4-DIHYDROXY-5-(PROPAN-2-YL)PHENYL]-4-(4-METHOXYPHENYL)-1,2-OXAZOL-5-YL}CYCLOPROPANECARBOXAMIDE'>FJ6</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ6:N-{3-[2,4-DIHYDROXY-5-(PROPAN-2-YL)PHENYL]-4-(4-METHOXYPHENYL)-1,2-OXAZOL-5-YL}CYCLOPROPANECARBOXAMIDE'>FJ6</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lwi RCSB], [http://www.ebi.ac.uk/pdbsum/4lwi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lwi RCSB], [http://www.ebi.ac.uk/pdbsum/4lwi PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: He, J | + | [[Category: He, J]] |
| - | [[Category: Li, J | + | [[Category: Li, J]] |
| - | [[Category: Shi, F | + | [[Category: Shi, F]] |
| - | [[Category: Xiong, B | + | [[Category: Xiong, B]] |
[[Category: Atp binding]] | [[Category: Atp binding]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Molecularchaperone]] | [[Category: Molecularchaperone]] | ||
[[Category: Rossmann fold]] | [[Category: Rossmann fold]] | ||
Revision as of 15:46, 24 December 2014
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6
| |||||||||||
Categories: He, J | Li, J | Shi, F | Xiong, B | Atp binding | Chaperone | Molecularchaperone | Rossmann fold
