Function
Survivin or apoptosis inhibitor 4 (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation.
Disease
IAP4 is found in human cancer cells and can serve as a cancer marker and as a target for chemotherapy.
Relevance
Structural highlights
3D structures of survivin
Updated on 04-August-2014
1e31 – hIAP4 – human
1f3h, 3ueg, 3ueh, 3uei – hIAP4 (mutant)
1xox – hIAP4 – NMR
1m4m – IAP4 – mouse
Survivin complex
2raw, 2rax – hIAP4 + Borealin N-terminal
2qfa – hIAP4 + Borealin N-terminal + inner centromere protein
4a0i – hIAP4 + shugoshin peptide
4a0j, 4a0n, 3uig, 3uii, 3ued – hIAP4 + histone H3 peptide
3uik, 3uec, 3uee, 3uef – hIAP4 (mutant) + histone H3 peptide
3uih – hIAP4 + diablo peptide
3uij – hIAP4 (mutant) + diablo peptide
References
