Function
Centromere proteins (CENP) X,S,W,T make up the kinetochore structure on chromatids where the spindle fibers attach during cell division to pull the chromatids apart.
• CENP-X is a component of the Fanconi Anemia core.
• CENP-B facilitates centromere formation.
• CENP-A is a component of modified nucleosome replacing hitone H3.
• CENP-E is a motor protein involved inchromosome movement.
• CENP-M is involved in the kinetochore assembly.
- Inner centromere protein (INCENP) is a component of the chromosomal passenger complex which regulates mitosis. INCENP are localized at the centromeres during mid-metaphase of the cell cycle.
Disease
Relevance
Structural highlights
3D structures of centromere protein
Updated on 05-August-2014
Centromere proteins X, S, W, T
3b0b – cCENP-X + CENP-S – chicken
4dra, 4e44, 4ne3, 4ne5, 4ne6 – hCENP-X + CENP-S – human
3vh5, 3vh6 – cCENP-X + CENP-S (mutant) + CENP-W + CENP-T C-terminal (mutant)
4drb, 4e45 – hCENP-X + CENP-S + Fanconi anemia group M protein
4ndy, 4ne1 – hCENP-X + CENP-S + DNA
3b0c, 3b0d – cCENP-T + CENP-W
3vza – cCENP-T residues 63-98 (mutant) + Spc24 + Spc25
Inner centromere protein
2bfx, 4b8l – fINCENP residues 798-840 + aurora kinase – frog
2bfy – fINCENP residues 798-840 + aurora kinase + hesperadin
2vgp, 2vrx, 3ztx, 4b8m – fINCENP residues 798-840 + aurora kinase + inhibitor
4af3 – hINCENP residues 835-903 + aurora kinase + inhibitor
2vgo – fINCENP residues 798-840 + aurora kinase + reversine
4c2v – fINCENP residues 798-840 + aurora kinase + barasertib
4c2w – fINCENP residues 798-840 + aurora kinase + AMPPNP
2qfa – hINCENP residues 1-47 + surviving + borealin
Centromere protein A
3nqu – hCENP-A + histone H4
3nqj – hCENP-A residues 60-140 + histone H4
3r45 – hCENP-A + histone H4 + Holliday junction recognition protein
3an2 – hCENP-A + histone H4 + histone H2A + histone H2B + DNA
Centromere protein B
1bw6 – hCENP-B DNA-binding domain - NMR
1ufi – hCENP-B dimerization domain
1hlv – hCENP-B DNA-binding domain + DNA
Centromere protein E
1t5c – hCENP-E motor domain
Centromere protein M
4p0t – hCENP-M
References
