Function
Neutrophil gelatinase-associated lipocalin (NGAL) or lipocalin-2 is involved in innate immunity by sequestering bacterial iron and thus preventing bacterial growth.
Disease
Relevance
NGAL is secreted in high levels into the blood following acute kidney injury and thus can be used as a biomarker for it.
Structural highlights
3D structures of neutrophil gelatinase-associated lipocalin
Updated on 02-September-2014
Neutrophil gelatinase-associated lipocalin
1dfv, 1qqs – hNGAL – human
3dtq – hNGAL (mutant)
1ngl – hNGAL - NMR
2k23 – NGAL – rat - NMR
3s26 – mNGAL – mouse
Neutrophil gelatinase-associated lipocalin complex
1l6m – hNGAL (mutant) + Fe+3
3pec, 3ped – hNGAL + Fe+3 + carboxymycobactin
1x71, 1x89, 1x8u – hNGAL (mutant) + Fe+3 + carboxymycobactin
3by0, 3cbc, 3cmp, 3hwd, 3hwf, 3hwg, 3i0a, 3k3l, 3t1d, 3u0d, 3u03 – hNGAL (mutant) + Fe+3 + enterobactin
4k19 – hNGAL (mutant) + Fe+3 + fluvibactin
3tf6 – hNGAL (mutant) + Eu+2+ enterobactin
3fw4, 3fw5 – hNGAL (mutant) + Fe+3 + catechol derivative
3cmp, 3hwe – hNGAL (mutant) + Fe+3 + bishacam
3dsz – hNGAL + Yt+3 + DTPA
4iaw, 4iax – hNGAL (mutant) + Yt+3 + DTPA
3tzs – hNGAL (mutant) + phenylurea
4gh7 – hNGAL (mutant) + fibronectin
3u9p – mNGAL + antibody
References
