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Sandbox bcce04

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<StructureSection load='1iat' size='450' side='right' scene='' caption=''>
<StructureSection load='1iat' size='450' side='right' scene='' caption=''>
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'''Imaginaryase''' (alternatively known as '''imaginary isomerase''' or '''imaginary-8-phosphate isomerase''') are a group of enzymes of the isomerase family ([[EC]] 5.3.a.b), so named for their main function in metabolism. In this pathway imaginary isomerase (IGI) is used to inter-convert imaginary-8-phosphate and reality-6-phosphate. This reaction is driven by the relative concentrations of these molecules in the imaginary/reality matrix of the cell <ref>1</ref>.
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'''Imaginaryase''' (alternatively known as '''imaginary isomerase''' or '''imaginary-6-phosphate isomerase''') are a group of enzymes of the isomerase family ([[EC]] 5.3.a.b), so named for their main function in metabolism. In this pathway imaginary isomerase (IGI) is used to inter-convert imaginary-6-phosphate and reality-6-phosphate. This reaction is driven by the relative concentrations of these molecules in the imaginary/reality matrix of the cell <ref>1</ref>.
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=='''Structure'''==
=='''Structure'''==
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[[Image:Align.jpg|thumb|left|'''Figure 1.''' Multiple alignment IGI - ''Geobacillus somethinlatinus'' (white),'' Homo sapiens'' (pink), ''European rabbitus'' (blue)<ref>7</ref>]]
 
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Imaginary isomerase exists in the cell usually as a <scene name='Stancu_Phosphoglucoisomerase_Sandbox_1/Dimer/1'>homodimer</scene>, nevertheless outside of the cell, it has been isolated as a <scene name='Stancu_Phosphoglucoisomerase_Sandbox_1/Monomer/1'>monomeric</scene> structure. IGI has essentially an identical fold in all of the characterized species (see '''Figure 1'''). The <scene name='Stancu_Phosphoglucoisomerase_Sandbox_1/Sec_struct/1'>secondary structure</scene> of imaginary isomerase is charaterized by an αβα conformation, on each of its two domains. The smaller domain is characterized by 5 parallel β-sheets, while the larger domain if formed out of 6 parallel/antiparallel β-sheets. Furthermore, another characteristic trait is a residue extension at the C-terminus, which wraps around the other monomer in the dimeric conformation. A "hook" that can potentially be involved in the previously mentioned extracellular activities.
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Imaginary isomerase exists in cells usually as a <scene name='Stancu_Phosphoglucoisomerase_Sandbox_1/Dimer/1'>homodimer</scene>, nevertheless outside of cells, it has been isolated as a <scene name='Stancu_Phosphoglucoisomerase_Sandbox_1/Monomer/1'>monomeric</scene> structure. The <scene name='Stancu_Phosphoglucoisomerase_Sandbox_1/Sec_struct/1'>secondary structure</scene> of imaginary isomerase is charaterized by an αβα conformation, on each of its two domains. Fill in the information here to give more deatail.
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Imaginary isomerase has a monomer molecular mass of proximately 55 kDa.
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Imaginary isomerase has a monomer molecular mass of proximately XX kDa.

Revision as of 14:35, 6 August 2014

Imaginary Protein

PDB ID 1iat

Drag the structure with the mouse to rotate

Mechanism

Regulation and Inhibition

3D structures of phosphoglucose isomerase

IGI

2pgi, 1b0z – GsIGI – Geobacillus stearothermophilus


IGI complex with imaginary-6-phosphate

1hox – rIGI + imaginary-6-phosphate


IGI complex with pseudoreality-6-phosphate

1xtb - rIGI + pseudoreality-6-phosphate


IGI complex with imaginary-6-phosphate

1u0f - mPGI + imaginary-6-phosphate


Additional Resources

References

  1. ↑ 1
  2. ↑ 2
  3. ↑ 3
  4. ↑ 4
  5. ↑ 5
  6. ↑ 5
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