1d90

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|PDB= 1d90 |SIZE=350|CAPTION= <scene name='initialview01'>1d90</scene>, resolution 1.700&Aring;
|PDB= 1d90 |SIZE=350|CAPTION= <scene name='initialview01'>1d90</scene>, resolution 1.700&Aring;
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DI:2&#39;-DEOXYINOSINE-5&#39;-MONOPHOSPHATE'>DI</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|ACTIVITY=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d90 OCA], [http://www.ebi.ac.uk/pdbsum/1d90 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d90 RCSB]</span>
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[[Category: modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:34:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:36:57 2008''

Revision as of 16:37, 30 March 2008

Image:1d90.gif


PDB ID 1d90

Drag the structure with the mouse to rotate
, resolution 1.700Å
Ligands: , , ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS


Overview

The structure of the synthetic deoxyoctamer d(GGIGCTCC) has been determined by single crystal X-ray diffraction techniques to a resolution of 1.7A. The sequence crystallises in space group P6(1), with unit cell dimensions a = b = 45.07, c = 45.49A. The refinement converged with a crystallographic residual R = 0.14 and the location of 81 solvent molecules. The octamer forms an A-DNA duplex with 6 Watson-Crick (G.C) base pairs and 2 inosine-thymine (I.T) pairs. Refinement of the structure shows it to be essentially isomorphous with that reported for d(GGGGCTCC) with the mispairs adopting a "wobble" conformation. Conformational parameters and base stacking interactions are compared to those for the native duplex d(GGGGCCCC) and other similar sequences. A rationale for the apparent increased crystal packing efficiency and lattice stability of the I.T octamer is given.

About this Structure

1D90 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs., Cruse WB, Aymani J, Kennard O, Brown T, Jack AG, Leonard GA, Nucleic Acids Res. 1989 Jan 11;17(1):55-72. PMID:2911488

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