4om7
From Proteopedia
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4om7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4om7 RCSB], [http://www.ebi.ac.uk/pdbsum/4om7 PDBsum]</span></td></tr> | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4om7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4om7 RCSB], [http://www.ebi.ac.uk/pdbsum/4om7 PDBsum]</span></td></tr> | ||
<table> | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Toll-like receptors (TLRs) are responsible for recognition of particular pathogens during the innate immune response and cytoplasmic Toll/interleukin-1 receptor (TIR) domain responsible for downstream signaling. TLR6 working with TLR2 can detect bacterial lipoprotein leading signal for nuclear factor-kappaB activation for immune response. To better understand TLR-mediated signaling event in the innate immune system, in this study, we report the first crystal structure of the TIR domain of TLR6 at 2.2A resolution. Our structure reveals novel homo-dimerization interfaces, which might be a critical for the interaction with TIR-containing adaptor proteins and itself. We also report structural similarities and differences of TLR6 with those of other TIR domains, which may be functionally relevant. | ||
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| + | Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR-TIR Interaction for Toll-Like Receptor Signaling Pathway.,Jang TH, Park HH J Mol Biol. 2014 Sep 23;426(19):3305-13. doi: 10.1016/j.jmb.2014.07.024. Epub, 2014 Jul 31. PMID:25088687<ref>PMID:25088687</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:07, 24 September 2014
Crystal structure of TIR domain of TLR6
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