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4twk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWK FirstGlance]. <br> | <table><tr><td colspan='2'>[[4twk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [http://www.ebi.ac.uk/pdbsum/4twk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [http://www.ebi.ac.uk/pdbsum/4twk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN]] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref> Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Ang, J H | + | [[Category: Ang, J H]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Berridge, G | + | [[Category: Berridge, G]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Burgess-Brown, N A | + | [[Category: Burgess-Brown, N A]] |
| - | [[Category: Bushell, S R | + | [[Category: Bushell, S R]] |
| - | [[Category: Carpenter, E P | + | [[Category: Carpenter, E P]] |
| - | [[Category: Chalk, R | + | [[Category: Chalk, R]] |
| - | [[Category: Chu, A | + | [[Category: Chu, A]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Dong, L | + | [[Category: Dong, L]] |
| - | [[Category: Dong, Y Y | + | [[Category: Dong, Y Y]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Faust, B | + | [[Category: Faust, B]] |
| - | [[Category: Goubin, S | + | [[Category: Goubin, S]] |
| - | [[Category: Grieben, M | + | [[Category: Grieben, M]] |
| - | [[Category: Kupinska, K | + | [[Category: Kupinska, K]] |
| - | [[Category: Mackenzie, A | + | [[Category: Mackenzie, A]] |
| - | [[Category: Mukhopadhyay, S | + | [[Category: Mukhopadhyay, S]] |
| - | [[Category: Pike, A C.W | + | [[Category: Pike, A C.W]] |
| - | [[Category: Quigley, A | + | [[Category: Quigley, A]] |
| - | [[Category: Shintre, C A | + | [[Category: Shintre, C A]] |
| - | [[Category: Shrestha, L | + | [[Category: Shrestha, L]] |
| - | [[Category: Strain-Damerell, C | + | [[Category: Strain-Damerell, C]] |
| - | [[Category: Tessitore, A | + | [[Category: Tessitore, A]] |
| - | [[Category: Wang, D | + | [[Category: Wang, D]] |
[[Category: Ion channel]] | [[Category: Ion channel]] | ||
[[Category: K2p]] | [[Category: K2p]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 17:41, 25 December 2014
Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
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Categories: Ang, J H | Arrowsmith, C H | Berridge, G | Bountra, C | Burgess-Brown, N A | Bushell, S R | Carpenter, E P | Chalk, R | Chu, A | Delft, F von | Dong, L | Dong, Y Y | Edwards, A M | Faust, B | Goubin, S | Grieben, M | Kupinska, K | Mackenzie, A | Mukhopadhyay, S | Pike, A C.W | Quigley, A | Shintre, C A | Shrestha, L | Strain-Damerell, C | Tessitore, A | Wang, D | Ion channel | K2p | Membrane protein | Transport protein
