4tzc
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4tzc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZC FirstGlance]. <br> | <table><tr><td colspan='2'>[[4tzc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EF2:S-THALIDOMIDE'>EF2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EF2:S-THALIDOMIDE'>EF2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tzc RCSB], [http://www.ebi.ac.uk/pdbsum/4tzc PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tzc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tzc RCSB], [http://www.ebi.ac.uk/pdbsum/4tzc PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRBN_MOUSE CRBN_MOUSE]] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chamberlain, P P | + | [[Category: Chamberlain, P P]] |
| - | [[Category: Delker, S | + | [[Category: Delker, S]] |
| - | [[Category: Leon, B | + | [[Category: Leon, B]] |
| - | [[Category: Pagarigan, B | + | [[Category: Pagarigan, B]] |
[[Category: Dcaf]] | [[Category: Dcaf]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Ubiquitin ligase]] | [[Category: Ubiquitin ligase]] | ||
Revision as of 19:31, 25 December 2014
Crystal Structure of Murine Cereblon in Complex with Thalidomide
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Categories: Chamberlain, P P | Delker, S | Leon, B | Pagarigan, B | Dcaf | Ligase | Ubiquitin ligase
