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Cyclin-dependent kinase

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Revision as of 09:01, 12 August 2014

Template:STRUCTURE 3rgf Cyclin-dependent kinase (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.

• For details on CDK2 see Cell Division Protein Kinase 2.
• CDK3 binds cyclin C and functions during the G1 phase.
• For details on CDK4 see Cyclin Dependent Kinase-4.

CDK5 binds p53 and functions during transcription.

• CDK6 binds cyclin D and functions during the G1 phase.
• CDK7 may serve as a direct link between transcription regulation and the cell cycle.
• CDK8 binds cyclin C and functions during transcription. • CDK12 phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation. • CDK16 plays a role in vescicle-mdiated transport processes and exocytosis.

1 3D structures of cyclin-dependent kinase
- 1.1 CDK2
- 1.2 CDK3
- 1.3 CDK4
- 1.4 CDK5
- 1.5 CDK6
- 1.6 CDK7
- 1.7 CDK8
- 1.8 CDK9
- 1.9 CDK12
- 1.10 CDK16

3D structures of cyclin-dependent kinase

Updated on 12-August-2014

CDK2

See Cell Division Protein Kinase 2

CDK3

1fpz – hCDK3 (mutant)

CDK4

CDK5

1h4l – hCDK5 + CDK5 activator
1ung, 1unh, 1unl - hCDK5 (mutant) + CDK5 activator + inhibitor
3o0g - hCDK5 + ATP analog + CDK5 activator

CDK6

1bi7 – hCDK6 + multiple tumor suppressor
1bi8, 1blx – hCDK6 + CDK protein inhibitor
1g3n – hCDK6 + cyclin D homolog + CDK protein inhibitor
1jow – hCDK6 + V-cyclin
3nup, 3nux, 4aua, 4ez5 – hCDK6 + inhibitor
1xo2, 2f2c, 2euf, 4tth – hCDK6 + V-cyclin + inhibitor

CDK7

1ua2 – hCDK7

CDK8

4g6l – hCDK8 + cyclin C
3rgf, 4f6s, 4f6u, 4f6w, 4f70, 4f7j, 4f7l, 4f7n – hCDK8 + cyclin C + inhibitor
4f7s – hCDK8 + cyclin C + phenylethyl-quinazolin-amine

CDK9

3blh, 4ec8, 4ec9 – hCDK9-P + cyclin T1 (mutant)
3blq – hCDK9-P + cyclin T1 (mutant) + ATP
3lq5, 3my1, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj – hCDK9-P + cyclin T1 (mutant) + inhibitor
3blr – hCDK9-P + cyclin T1 + flavopiridol
3mi9, 3mia – hCDK9-P + cyclin T1 + HIV-1 TAT
4or5, 4ogr – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein
4imy – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein

CDK12

4cjy, 4un0 – hCDK12-P + cyclin K
4nst – hCDK12-P + cyclin K + AlF3
4cxa – hCDK12-P + cyclin K + AMPPNP

CDK16

3mtl – hCDK16 (mutant) + indirubin

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-'''Cyclin-dependent kinase''' (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle.  CDKs are small proteins which contain just a kinase domain.  In order to function, CDK binds the regulatory protein cyclin.  CDKs phosphorylate their substrates at a consensus tetrapeptide.  The CDK classes differ by the binding cyclin and their function in human.  For details on '''CDK2''' see [[Cell Division Protein Kinase 2]].  CDK3 binds cyclin C and functions during the G1 phase. For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]].  '''CDK5''' binds p53 and functions during transcription.  '''CDK6''' binds cyclin D and functions during the G1 phase.  '''CDK8''' binds cyclin C and functions during transcription.   '''CDK9''' facilitates the transition from abortive to productive transcription elongation by phosphorylating the C-terminal domain of the large subunit of RNA polymerase.  '''CDK12''' is required for RNA splicing.
+'''Cyclin-dependent kinase''' (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle.  CDKs are small proteins which contain just a kinase domain.  In order to function, CDK binds the regulatory protein cyclin.  CDKs phosphorylate their substrates at a consensus tetrapeptide.  The CDK classes differ by the binding cyclin and their function in human.<br />
+•	For details on '''CDK2''' see [[Cell Division Protein Kinase 2]].  <br />
+•	'''CDK3''' binds cyclin C and functions during the G1 phase. <br />
+•	For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br />
+*      '''CDK5''' binds p53 and functions during transcription. <br />
+•      '''CDK6''' binds cyclin D and functions during the G1 phase. <br />
+•	'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle.<br />
+•      '''CDK8''' binds cyclin C and functions during transcription.
+•	'''CDK12''' phosphorylates the C-terminal domain of the large subunit of RNA polymerase II.  Acts as a regulator of transcription elongation.
+•	'''CDK16''' plays a role in vescicle-mdiated transport processes and exocytosis.
 ==3D structures of cyclin-dependent kinase==
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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-===CDK2  [[Cell Division Protein Kinase 2]]===
+===CDK2===
+See [[Cell Division Protein Kinase 2]]
 ===CDK3===
@@ Line 18: / Line 29: @@
 [[1fpz]] – hCDK3 (mutant)
-===CDK4 [[Cyclin Dependent Kinase-4]]===
+===CDK4===
 ===CDK5===