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2wbh

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Revision as of 21:05, 25 December 2014

Icosahedral particle of covalent coat protein dimer of bacteriophage MS2

Structural highlights

2wbh is a 3 chain structure with sequence from Bpms2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2b2e, 6msf, 2bs0, 2iz9, 7msf, 2b2g, 2c4q, 2c4y, 1zdj, 2c4z, 2c51, 2bny, 1u1y, 2vtu, 2bs1, 1msc, 1mvb, 2izn, 1mst, 1aq4, 2ms2, 2c50, 1zdi, 1zdk, 1aq3, 1mva, 5msf, 2b2d, 1bms, 1zdh, 1zse, 2bq5, 2iz8, 2izm, 2bu1
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[COAT_BPMS2] Forms the phage shell; binds to the phage RNA.

Publication Abstract from PubMed

Particles formed by the bacteriophage MS2 coat protein mutants with insertions in their surface loops induce a strong immune response against the inserted epitopes. The covalent dimers created by fusion of two copies of the coat protein gene are more tolerant to various insertions into the surface loops than the single subunits. We determined a 4.7-A resolution crystal structure of an icosahedral particle assembled from covalent dimers and compared its stability with wild-type virions. The structure resembled the wild-type virion except for the intersubunit linker regions. The covalent dimer orientation was random with respect to both icosahedral twofold and quasi-twofold symmetry axes. A fraction of the particles was unstable in phosphate buffer because of assembly defects. Our results provide a structural background for design of modified covalent coat protein dimer subunits for use in immunization.

Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2.,Plevka P, Tars K, Liljas L Protein Sci. 2009 Aug;18(8):1653-61. PMID:19521994^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Plevka P, Tars K, Liljas L. Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2. Protein Sci. 2009 Aug;18(8):1653-61. PMID:19521994 doi:10.1002/pro.184

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wbh"

@@ Line 3: / Line 3: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2wbh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpms2 Bpms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBH FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b2e|2b2e]], [[6msf|6msf]], [[2bs0|2bs0]], [[2iz9|2iz9]], [[7msf|7msf]], [[2b2g|2b2g]], [[2c4q|2c4q]], [[2c4y|2c4y]], [[1zdj|1zdj]], [[2c4z|2c4z]], [[2c51|2c51]], [[2bny|2bny]], [[1u1y|1u1y]], [[2vtu|2vtu]], [[2bs1|2bs1]], [[1msc|1msc]], [[1mvb|1mvb]], [[2izn|2izn]], [[1mst|1mst]], [[1aq4|1aq4]], [[2ms2|2ms2]], [[2c50|2c50]], [[1zdi|1zdi]], [[1zdk|1zdk]], [[1aq3|1aq3]], [[1mva|1mva]], [[5msf|5msf]], [[2b2d|2b2d]], [[1bms|1bms]], [[1zdh|1zdh]], [[1zse|1zse]], [[2bq5|2bq5]], [[2iz8|2iz8]], [[2izm|2izm]], [[2bu1|2bu1]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b2e|2b2e]], [[6msf|6msf]], [[2bs0|2bs0]], [[2iz9|2iz9]], [[7msf|7msf]], [[2b2g|2b2g]], [[2c4q|2c4q]], [[2c4y|2c4y]], [[1zdj|1zdj]], [[2c4z|2c4z]], [[2c51|2c51]], [[2bny|2bny]], [[1u1y|1u1y]], [[2vtu|2vtu]], [[2bs1|2bs1]], [[1msc|1msc]], [[1mvb|1mvb]], [[2izn|2izn]], [[1mst|1mst]], [[1aq4|1aq4]], [[2ms2|2ms2]], [[2c50|2c50]], [[1zdi|1zdi]], [[1zdk|1zdk]], [[1aq3|1aq3]], [[1mva|1mva]], [[5msf|5msf]], [[2b2d|2b2d]], [[1bms|1bms]], [[1zdh|1zdh]], [[1zse|1zse]], [[2bq5|2bq5]], [[2iz8|2iz8]], [[2izm|2izm]], [[2bu1|2bu1]]</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbh RCSB], [http://www.ebi.ac.uk/pdbsum/2wbh PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbh RCSB], [http://www.ebi.ac.uk/pdbsum/2wbh PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/COAT_BPMS2 COAT_BPMS2]] Forms the phage shell; binds to the phage RNA.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 </StructureSection>
 [[Category: Bpms2]]
-[[Category: Liljas, L.]]
+[[Category: Liljas, L]]
-[[Category: Plevka, P.]]
+[[Category: Plevka, P]]
-[[Category: Tars, K.]]
+[[Category: Tars, K]]
 [[Category: Capsid protein]]
 [[Category: Covalent dimer]]

2wbh

From Proteopedia

Revision as of 21:05, 25 December 2014

Icosahedral particle of covalent coat protein dimer of bacteriophage MS2

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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